Long-term anatomical and functional outcomes after autokeratoplasty
Author
Sanjuán, Pablo
Julio, Gemma
Bolaños, Jennifer
De Toledo, Juan Álvarez
García de Oteyza, Gonzalo
Temprano, José
Barraquer, Rafael Ignacio
Publication date
2021ISSN
0007-1161
Abstract
Background: To evaluate the anatomical and functional outcomes of autologous contralateral penetrating keratoplasty (autokeratoplasty). Methods: Kaplan-Meier survival analyses were retrospectively performed. Anatomical failure was defined as regraft or graft permanently cloudy at any time during follow-up. Functional failure was defined as the final best-corrected visual acuity (BCVA) <20/400. Results: Thirty-one eyes of 31 patients (19 men), with a mean age of 52±18 years (range 15–81 years) were studied during a mean follow-up of 11.3 years (from 13 months to 48 years). At 12 months postoperatively, all the recipient eyes showed a transparent cornea, but 23% showed functional failure. At the final followup, 16 recipient eyes (52%) showed anatomical and functional success. Twenty-three eyes (74%) showed a clear cornea and 68% reached a better BCVA when compared with preoperative measurements. Nevertheless, 13/31 eyes (42%) displayed functional failure. The accumulative probabilities for anatomical success were 100%, 72% and 48% and 77%, 59% and 29% for functional success at 1, 10 and 40 years, respectively. The most common risk factor for failure was progression of previous glaucoma in 50% of the anatomical failures and in 77% of the functional failures. Conclusions: Autokeratoplasty could be a successful long-term option in patients having one eye with a clear cornea but with irreversible visual dysfunction and the contralateral eye having favourable visual potential limited only by a completely opacified cornea. Progression of previous glaucoma was the most important risk factor for long-term cornea decompensation and visual functional failure in the sample.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
617 - Surgery. Orthopaedics. Ophthalmology
Keywords
Oftalmologia
Oftalmología
Ophtalmology
Pages
5
Publisher
BMJ Publishing Group
Collection
105
Is part of
British Journal of Ophthalmology
Citation
Sanjuán, Pablo; Julio, Gemma; Bolaños, Jennifer [et al.]. Long-term anatomical and functional outcomes after autokeratoplasty. British Journal of Ophthalmology, 2021, 105, p.1063-1068. Disponible en: <https://bjo.bmj.com/content/105/8/1063.info>. Fecha de acceso: 19 ene. 2024. DOI: 10.1136/bjophthalmol-2021-319985
This item appears in the following Collection(s)
- Ciències de la Salut [740]
Rights
© Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.