Targeting the Src N-terminal regulatory element in cancer
Autor/a
Mezquita, Betlem
Reyes Farias, Marjorie
Pons, Miquel
Data de publicació
2023ISSN
1949-2553
Resum
The signaling pathways displayed by cancer cells are often composed by the same components than the physiological ones, yet the overall result is a pathological deregulation. The non-receptor protein tyrosine kinase Src is a good example. Src is the first described proto-oncogene and a demonstrated player in cancer progression, as it affects proliferation, invasion, survival, cancer stemness, and drug resistance. Src activation is linked to poor prognosis in many cancer types, yet mutations in this protein are rarely observed. In addition, being a demonstrated cancer target, unspecific inhibition of the kinase activity has proven inefficient in clinics since the inhibition of Src in non-cancerous cells results in unacceptable toxicity. Thus, there is a need for new target regions in Src that could inhibit Src activity only in certain cell types, e.g., cancer cells, while maintaining the normal physiological activity in healthy cells. The Src N-terminal regulatory element (SNRE) includes the poorly studied intrinsically disordered region with unique sequences for each of the members of the Src family. In this perspective, we discuss the non-canonical regulatory mechanisms involving the SNRE and their potential use as oncotargets.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
English
Matèries (CDU)
61 - Medicina
616 - Patologia. Medicina clínica. Oncologia
Paraules clau
Src quinases de la família
Proteïnes intrínsecament desordenades
SNRE
Fàrmacs selectius de tipus cel·lular
Resistència als fàrmacs
Src quinasas de la familia
Proteínas intrínsecamente desordenadas
SNRE
Fármacos selectivos de tipo celular
Resistencia a las drogas
Src family kinases
Intrinsically disordered proteins
SNRE
Cell-type selective drugs
Drug resistance
Pàgines
11
Publicat per
Impact Journals
Col·lecció
14
Publicat a
Oncotarget
Citació
Mezquita, Betlem; Reyes Farias, Marjorie; Pons, Miquel. Targeting the Src N-terminal regulatory element in cancer. Oncotarget, 2023, 14, 503-513. Disponible en: <https://www.oncotarget.com/article/28434/text/>. Fecha de acceso: 7 jun. 2023. DOI: 10.18632/oncotarget.28434
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Drets
© 2023 Mezquita et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Excepte que s'indiqui una altra cosa, la llicència de l'ítem es descriu com https://creativecommons.org/licenses/by/3.0/