Targeting carnitine palmitoyltransferase 1 isoforms in the hypothalamus: a promising strategy to regulate energy balance
Autor/a
Rodríguez-Rodríguez, Rosalía
Fosch, Anna
Garcia-Chica, Jesús
Zagmutt, Sebastián
Casals Farré, Nuria
Data de publicació
2023ISSN
1365-2826
Resum
Tackling the growing incidence and prevalence of obesity urgently requires uncovering new molecular pathways with therapeutic potential. The brain, and in particular the hypothalamus, is a major integrator of metabolic signals from peripheral tissues that regulate functions such as feeding behavior and energy expenditure. In obesity, hypothalamic capacity to sense nutritional status and regulate these functions is altered. An emerging line of research is that hypothalamic lipid metabolism plays a critical role in regulating energy balance. Here, we focus on the carnitine palmitoyltransferase 1 (CPT1) enzyme family responsible for long-chain fatty acid metabolism. The evidence suggests that two of its isoforms expressed in the brain, CPT1A and CPT1C, play a crucial role in hypothalamic lipid metabolism, and their promise as targets in food intake and bodyweight management is currently being intensively investigated. In this review we describe and discuss the metabolic actions and potential up- and downstream effectors of hypothalamic CPT1 isoforms, and posit the need to develop innovative nanomedicine platforms for selective targeting of CPT1 and related nutrient sensors in specific brain areas as potential next-generation therapy to treat obesity.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
English
Matèries (CDU)
61 - Medicina
616.4 - Patologia del sistema limfàtic, òrgans hematopoètics, endocrins
Paraules clau
CPT1A
CPT1C
Hipotàlem
Metabolisme lipídic
Obesitat
CPT1A
CPT1C
Hipotálamo
Metabolismo de lípidos
Obesidad
CPT1A
CPT1C
Hypothalamus
Lipid metabolism
Obesity
Pàgines
9
Publicat per
John Wiley & Sons
Publicat a
Journal of Neuroendocrinology
Citació
Rodríguez-Rodríguez, Rosalía; Fosch, Anna; Garcia-Chica, Jesús [et al.]. Targeting carnitine palmitoyltransferase 1 isoforms in the hypothalamus: a promising strategy to regulate energy balance. Journal of Neuroendocrinology, 2023, e13234. Disponible en: <https://onlinelibrary.wiley.com/doi/full/10.1111/jne.13234>. Fecha de acceso: 13 feb. 2023. DOI: 10.1111/jne.13234
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Drets
This is an open access article under the terms of theCreative Commons Attribution-NonCommercial-NoDerivsLicense, which permits use and distribution in anymedium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.© 2023 The Authors.Journal of Neuroendocrinologypublished by John Wiley & Sons Ltd on behalf of British Society for Neuroendocrinology.
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