Browsing by Subject "CPT1C"
Now showing items 1-14 of 14
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Central regulation of brown fat thermogenesis in response to saturated or unsaturated long-chain fatty acids
(International Journal of Molecular Sciences, 2023)Sensing of long-chain fatty acids (LCFA) in the hypothalamus modulates energy balance, and its disruption leads to obesity. To date, the effects of saturated or unsaturated LCFA on hypothalamic-brown ... -
CPT1C and endocannabinoids as hypothalamic players in early stages of obesity development
(Date of defense: 2019-12-10)Obesity prevalence in worldwide population is increasing every day due to an imbalance between the energy intake and the energy expenditure. Rich-caloric food is highly palatable and easily accessible, ... -
CPT1C deficiency in SF1 neurons impairs early metabolic adaptation to dietary fats, leading to obesity
(Molecular Metabolism, 2025)Objectives: SF1 neurons of the ventromedial hypothalamus (VMH) play a pivotal role in regulating body weight and adiposity, particularly in response to a high-fat diet (HFD), as well as in the recovery ... -
Cpt1c downregulation causes plasma membrane remodelling and anthracycline resistance in breast cancer
(International Journal of Molecular Sciences, 2023)Breast cancer (BC) is the most common malignancy in women worldwide. While the main systemic treatment option is anthracycline-containing chemotherapy, chemoresistance continues to be an obstacle to ... -
CPT1C is required for synaptic plasticity and oscillatory activity that supports motor, associative and non-associative learning
(The Journal of Physiology, 2023)Carnitine palmitoyltransferase 1c (CPT1C) is a neuron-specific protein widely distributed throughout the CNS and highly expressed in discrete brain areas including the hypothalamus, hippocampus, amygdala ... -
CPT1C promotes human mesenchymal stem cells survival under glucose deprivation through the modulation of autophagy
(Scientific Reports, 2018-05-03)Human mesenchymal stem cells (hMSCs) are widely used in regenerative medicine. In some applications, they must survive under low nutrient conditions engendered by avascularity. Strategies to improve ... -
CPT1C-ABHD6 interaction in hypothalamic neurons: implications for bis (monoacylglycero) phosphate metabolism and the endolysosomal system
(Date of defense: 2024-02-14)El sistema endolisosomal juga un paper crític en la funció neuronal i ha emergit com a un potencial objectiu per al tractament de diverses malalties neuronals, com els trastorns neurodegeneratius i fins ... -
CPT1C-dependent regulation of GluA1 trafficking under metabolic stress
(Date of defense: 2019-12-10)Carnitine palmitoyltransferase 1C (CPT1C) is the brain-specific isoform of the CPT1 family which is located at the endoplasmic reticulum (ER) of neurons and exhibits low catalytic activity, but still ... -
Mechanisms of CPT1C-Dependent AMPAR trafficking enhancement
(Frontiers in Molecular Neuroscience, 2018-08-08)In neurons, AMPA receptor (AMPAR) function depends essentially on their constituent components: the ion channel forming subunits and ion channel associated proteins. On the other hand, AMPAR trafficking ... -
Nutrient-mediated regulation of AMPAR receptors’ trafficking through the malonyl-CoA – CPT1C axis
(Date of defense: 2024-02-15)Actualment hi ha un creixent interès en l'impacte de les dietes en la cognició. És àmpliament conegut que el cervell requereix una gran quantitat d'energia per dur a terme les seves funcions vitals. La ... -
Papel de CPT1C en el desarrollo axonal y en el transporte de los endosomas tardíos
(Date of defense: 2018-03-23)La paraplejía espástica hereditaria agrupa un conjunto de desórdenes neurodegenerativos caracterizados por espasticidad y rigidez muscular. Todos ellos están relacionados clínica y patológicamente con ... -
Rol de CPT1C en la supervivencia de las células madre mesenquimales
(Date of defense: 2016-09-06)La carnitina palmitoiltransferasa 1C (CPT1C) pertenece a la familia de enzimas CPT1, las cuales controlan la entrada de ácidos grasos al lumen de la mitocondria para su posterior oxidación. Sin embargo, ... -
Role of CPT1C in breast cancer development and chemoresistance
(Date of defense: 2021-07-14)Carnitine palmitoyl transferase 1 (CPT1) are enzymes that catalyze the conversion of long-chain acyl-CoA to acyl-carnitines, to transport long-chain fatty acids across intracellular membranes. CPT1C ... -
Targeting carnitine palmitoyltransferase 1 isoforms in the hypothalamus: a promising strategy to regulate energy balance
(Journal of Neuroendocrinology, 2023)Tackling the growing incidence and prevalence of obesity urgently requires uncovering new molecular pathways with therapeutic potential. The brain, and in particular the hypothalamus, is a major integrator ...