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Impact of COVID-19 lockdown on the nasopharyngeal microbiota of children and adults self-confined at home
dc.contributor.author | Rocafort, Muntsa | |
dc.contributor.author | Henares, Desiree | |
dc.contributor.author | Brotons, Pedro | |
dc.contributor.author | Launes, Cristian | |
dc.contributor.author | de Sevilla, Mariona F | |
dc.contributor.author | Fumado, Victoria | |
dc.contributor.author | Barrabeig, Irene | |
dc.contributor.author | Arias, Sara | |
dc.contributor.author | Redin, Alba | |
dc.contributor.author | Ponomarenko, Julia | |
dc.contributor.author | Melé-Casas, Maria | |
dc.contributor.author | Millat-Martinez, Pere | |
dc.contributor.author | Claverol, Joana | |
dc.contributor.author | Balanza, Nuria | |
dc.contributor.author | Mira, Alex | |
dc.contributor.author | Garcia-Garcia, Juan J. | |
dc.contributor.author | Bassat, Quique | |
dc.contributor.author | Jordan, Iolanda | |
dc.contributor.author | Muñoz-Almagro, Carmen | |
dc.date.accessioned | 2022-10-03T13:46:52Z | |
dc.date.available | 2022-10-03T13:46:52Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Rocafort, Muntsa; Henares, Desiree; Brotons, Pedro [et al.]. Impact of COVID-19 lockdown on the nasopharyngeal microbiota of children and adults self-confined at home. Viruses, 2022, 14(7), 1521. Disponible en: <https://www.mdpi.com/1999-4915/14/7/1521>. Fecha de acceso: 3 oct. 2022. DOI: 10.3390/v14071521 | ca |
dc.identifier.issn | 1999-4915 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12328/3414 | |
dc.description.abstract | The increased incidence of COVID-19 cases and deaths in Spain in March 2020 led to the declaration by the Spanish government of a state of emergency imposing strict confinement measures on the population. The objective of this study was to characterize the nasopharyngeal microbiota of children and adults and its relation to SARS-CoV-2 infection and COVID-19 severity during the pandemic lockdown in Spain. This cross-sectional study included family households located in metropolitan Barcelona, Spain, with one adult with a previous confirmed COVID-19 episode and one or more exposed co-habiting child contacts. Nasopharyngeal swabs were used to determine SARS-CoV-2 infection status, characterize the nasopharyngeal microbiota and determine common respiratory DNA/RNA viral co-infections. A total of 173 adult cases and 470 exposed children were included. Overall, a predominance of Corynebacterium and Dolosigranulum and a limited abundance of common pathobionts including Haemophilus and Streptococcus were found both among adults and children. Children with current SARS-CoV-2 infection presented higher bacterial richness and increased Fusobacterium, Streptococcus and Prevotella abundance than non-infected children. Among adults, persistent SARS-CoV-2 RNA was associated with an increased abundance of an unclassified member of the Actinomycetales order. COVID-19 severity was associated with increased Staphylococcus and reduced Dolosigranulum abundance. The stringent COVID-19 lockdown in Spain had a significant impact on the nasopharyngeal microbiota of children, reflected in the limited abundance of common respiratory pathobionts and the predominance of Corynebacterium, regardless of SARS-CoV-2 detection. COVID-19 severity in adults was associated with decreased nasopharynx levels of healthy commensal bacteria. | en |
dc.format.extent | 17 | ca |
dc.language.iso | eng | ca |
dc.publisher | MDPI | ca |
dc.relation.ispartof | Viruses | ca |
dc.relation.ispartofseries | 14;7 | |
dc.relation.uri | https://www.mdpi.com/1999-4915/14/7/1521 | ca |
dc.rights | This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | en |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject.other | Microbiota nasofaríngia | ca |
dc.subject.other | Nens | ca |
dc.subject.other | Adults | ca |
dc.subject.other | COVID-19 | ca |
dc.subject.other | Microbiota nasofaríngea | es |
dc.subject.other | Niños | es |
dc.subject.other | Adultos | es |
dc.subject.other | COVID-19 | es |
dc.subject.other | Nasopharyngeal microbiota | en |
dc.subject.other | Children | en |
dc.subject.other | Adults | en |
dc.subject.other | COVID-19 | en |
dc.title | Impact of COVID-19 lockdown on the nasopharyngeal microbiota of children and adults self-confined at home | en |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.subject.udc | 61 | ca |
dc.identifier.doi | https://dx.doi.org/10.3390/v14071521 | ca |
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