Impact of COVID-19 lockdown on the nasopharyngeal microbiota of children and adults self-confined at home
Autor/a
Rocafort, Muntsa
Henares, Desiree
Brotons, Pedro
Launes, Cristian
de Sevilla, Mariona F
Fumado, Victoria
Barrabeig, Irene
Arias, Sara
Redin, Alba
Ponomarenko, Julia
Millat-Martinez, Pere
Balanza, Nuria
Mira, Alex
Garcia-Garcia, Juan J.
Bassat, Quique
Data de publicació
2022ISSN
1999-4915
Resum
The increased incidence of COVID-19 cases and deaths in Spain in March 2020 led to the declaration by the Spanish government of a state of emergency imposing strict confinement measures on the population. The objective of this study was to characterize the nasopharyngeal microbiota of children and adults and its relation to SARS-CoV-2 infection and COVID-19 severity during the pandemic lockdown in Spain. This cross-sectional study included family households located in metropolitan Barcelona, Spain, with one adult with a previous confirmed COVID-19 episode and one or more exposed co-habiting child contacts. Nasopharyngeal swabs were used to determine SARS-CoV-2 infection status, characterize the nasopharyngeal microbiota and determine common respiratory DNA/RNA viral co-infections. A total of 173 adult cases and 470 exposed children were included. Overall, a predominance of Corynebacterium and Dolosigranulum and a limited abundance of common pathobionts including Haemophilus and Streptococcus were found both among adults and children. Children with current SARS-CoV-2 infection presented higher bacterial richness and increased Fusobacterium, Streptococcus and Prevotella abundance than non-infected children. Among adults, persistent SARS-CoV-2 RNA was associated with an increased abundance of an unclassified member of the Actinomycetales order. COVID-19 severity was associated with increased Staphylococcus and reduced Dolosigranulum abundance. The stringent COVID-19 lockdown in Spain had a significant impact on the nasopharyngeal microbiota of children, reflected in the limited abundance of common respiratory pathobionts and the predominance of Corynebacterium, regardless of SARS-CoV-2 detection. COVID-19 severity in adults was associated with decreased nasopharynx levels of healthy commensal bacteria.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
Anglès
Matèries (CDU)
61 - Medicina
Paraules clau
Microbiota nasofaríngia
Nens
Adults
COVID-19
Microbiota nasofaríngea
Niños
Adultos
COVID-19
Nasopharyngeal microbiota
Children
Adults
COVID-19
Pàgines
17
Publicat per
MDPI
Col·lecció
14;7
Publicat a
Viruses
Citació
Rocafort, Muntsa; Henares, Desiree; Brotons, Pedro [et al.]. Impact of COVID-19 lockdown on the nasopharyngeal microbiota of children and adults self-confined at home. Viruses, 2022, 14(7), 1521. Disponible en: <https://www.mdpi.com/1999-4915/14/7/1521>. Fecha de acceso: 3 oct. 2022. DOI: 10.3390/v14071521
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Drets
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