ADP-ribose–derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling
Author
Wright, Roni
LeDily, Francois
Soronellas, Daniel
Pohl, Andy
Bonet, Jaume
Nacht, A. S.
Vicent, Guillermo Pablo
Wierer, Michael
Oliva, Baldo
Beato, Miguel
Publication date
2016ISBN
0036-8075
ISSN
Beato
Abstract
Key nuclear processes in eukaryotes, including DNA replication, repair, and gene regulation, require extensive chromatin remodeling catalyzed by energy-consuming enzymes. It remains unclear how the ATP demands of such processes are met in response to rapid stimuli. We analyzed this question in the context of the massive gene regulation changes induced by progestins in breast cancer cells and found that ATP is generated in the cell nucleus via the hydrolysis of poly(ADP-ribose) to ADP-ribose. In the presence of pyrophosphate, ADP-ribose is used by the pyrophosphatase NUDIX5 to generate nuclear ATP. The nuclear source of ATP is essential for hormone-induced chromatin remodeling, transcriptional regulation, and cell proliferation.
Document Type
Article
Document version
Submitted version
Language
English
Subject (CDU)
57 - Biological sciences in general
Keywords
Eucariotes
ADN
Regulació gènica
Cromatina catalitzada
Enzims
Cèl·lules canceroses de mama
Hormones
Regulació transcripcional
Proliferació cel·lular
Eucariotas
ADN
Regulación génica
Cromatina catalizada
Enzimas
Células cancerosas de mama
Hormonas
Regulación transcripcional
Proliferación celular
Eukaryotes
DNA
Gene regulation
Catalyzed chromatin
Enzymes
Breast cancer cells
Hormones
Transcriptional regulation
Cell proliferation
Pages
36
Publisher
American Association for the Advancement of Science
Collection
352; 6290
Is part of
Science
Citation
Wright, Roni H. G.; LeDily, Francois; Soronellas, Daniel [et al.]. ADP-ribose–derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling. Science, 2016, 352(6290), p. 1221-1225. Disponible en: <https://www.science.org/doi/10.1126/science.aad9335<. Fecha de acceso: 26 ene. 2022. DOI: 10.1126/science.aad9335
This item appears in the following Collection(s)
- Ciències Bàsiques [65]
Rights
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