dc.contributor.author | Wright, Roni | |
dc.contributor.author | LeDily, Francois | |
dc.contributor.author | Soronellas, Daniel | |
dc.contributor.author | Pohl, Andy | |
dc.contributor.author | Bonet, Jaume | |
dc.contributor.author | Nacht, A. S. | |
dc.contributor.author | Vicent, Guillermo Pablo | |
dc.contributor.author | Wierer, Michael | |
dc.contributor.author | Oliva, Baldo | |
dc.contributor.author | Beato, Miguel | |
dc.date.accessioned | 2022-01-26T16:33:12Z | |
dc.date.available | 2022-01-26T16:33:12Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Wright, Roni H. G.; LeDily, Francois; Soronellas, Daniel [et al.]. ADP-ribose–derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling. Science, 2016, 352(6290), p. 1221-1225. Disponible en: <https://www.science.org/doi/10.1126/science.aad9335<. Fecha de acceso: 26 ene. 2022. DOI: 10.1126/science.aad9335 | ca |
dc.identifier.isbn | 0036-8075 | ca |
dc.identifier.issn | Beato | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12328/3103 | |
dc.description.abstract | Key nuclear processes in eukaryotes, including DNA replication, repair, and gene regulation, require extensive chromatin remodeling catalyzed by energy-consuming enzymes. It remains unclear how the ATP demands of such processes are met in response to rapid stimuli. We analyzed this question in the context of the massive gene regulation changes induced by progestins in breast cancer cells and found that ATP is generated in the cell nucleus via the hydrolysis of poly(ADP-ribose) to ADP-ribose. In the presence of pyrophosphate, ADP-ribose is used by the pyrophosphatase NUDIX5 to generate nuclear ATP. The nuclear source of ATP is essential for hormone-induced chromatin remodeling, transcriptional regulation, and cell proliferation. | en |
dc.format.extent | 36 | ca |
dc.language.iso | eng | ca |
dc.publisher | American Association for the Advancement of Science | ca |
dc.relation.ispartof | Science | ca |
dc.relation.ispartofseries | 352;6290 | |
dc.rights | © 2022 American Association for the Advancement of Science. All rights reserved. AAAS is a partner of HINARI, AGORA, OARE, CHORUS, CLOCKSS, CrossRef and COUNTER. Science ISSN 0036-8075. | en |
dc.subject.other | Eucariotes | ca |
dc.subject.other | ADN | ca |
dc.subject.other | Regulació gènica | ca |
dc.subject.other | Cromatina catalitzada | ca |
dc.subject.other | Enzims | ca |
dc.subject.other | Cèl·lules canceroses de mama | ca |
dc.subject.other | Hormones | ca |
dc.subject.other | Regulació transcripcional | ca |
dc.subject.other | Proliferació cel·lular | ca |
dc.subject.other | Eucariotas | es |
dc.subject.other | ADN | es |
dc.subject.other | Regulación génica | es |
dc.subject.other | Cromatina catalizada | es |
dc.subject.other | Enzimas | es |
dc.subject.other | Células cancerosas de mama | es |
dc.subject.other | Hormonas | es |
dc.subject.other | Regulación transcripcional | es |
dc.subject.other | Proliferación celular | es |
dc.subject.other | Eukaryotes | en |
dc.subject.other | DNA | en |
dc.subject.other | Gene regulation | en |
dc.subject.other | Catalyzed chromatin | en |
dc.subject.other | Enzymes | en |
dc.subject.other | Breast cancer cells | en |
dc.subject.other | Hormones | en |
dc.subject.other | Transcriptional regulation | en |
dc.subject.other | Cell proliferation | en |
dc.title | ADP-ribose–derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling | en |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/submittedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.subject.udc | 57 | ca |
dc.identifier.doi | https://dx.doi.org/10.1126/science.aad9335 | ca |