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Immobilization of BMP-2 and VEGF within multilayered polydopamine-coated scaffolds and the resulting osteogenic and angiogenic synergy of co-cultured human mesenchymal stem cells and human endothelial progenitor cells
dc.contributor.author | Godoy-Gallardo, Maria | |
dc.contributor.author | Portolés-Gil, Núria | |
dc.contributor.author | López-Periago, Ana M. | |
dc.contributor.author | Domingo, Concepción | |
dc.contributor.author | Hosta-Rigau, Leticia | |
dc.date.accessioned | 2022-01-17T13:23:16Z | |
dc.date.available | 2022-01-17T13:23:16Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Godoy-Gallardo, Maria; Portolés-Gil, Núria; López-Periago, Ana M. [et al.]. Immobilization of BMP-2 and VEGF within multilayered polydopamine-coated scaffolds and the resulting osteogenic and angiogenic synergy of co-cultured human mesenchymal stem cells and human endothelial progenitor cells. International Journal of Molecular Sciences, 2020, 21(17), 6418. Disponible en: <https://www.mdpi.com/1422-0067/21/17/6418>. Fecha de acceso: 17 ene. 2022. DOI: 10.3390/ijms21176418 | ca |
dc.identifier.issn | 1422-0067 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12328/3067 | |
dc.description.abstract | We have previously reported the fabrication of a polycaprolactone and hydroxyapatite composite scaffold incorporating growth factors to be used for bone regeneration. Two growth factors were incorporated employing a multilayered coating based on polydopamine (PDA). In particular, Bone morphogenetic protein-2 (BMP-2) was bound onto the inner PDA layer while vascular endothelial growth factor (VEGF) was immobilized onto the outer one. Herein, the in vitro release of both growth factors is evaluated. A fastest VEGF delivery followed by a slow and more sustained release of BMP-2 was demonstrated, thus fitting the needs for bone tissue engineering applications. Due to the relevance of the crosstalk between bone-promoting and vessel-forming cells during bone healing, the functionalized scaffolds are further assessed on a co-culture setup of human mesenchymal stem cells and human endothelial progenitor cells. Osteogenic and angiogenic gene expression analysis indicates a synergistic effect between the growth factor-loaded scaffolds and the co-culture conditions. Taken together, these results indicate that the developed scaffolds hold great potential as an efficient platform for bone-tissue applications. | en |
dc.format.extent | 25 | ca |
dc.language.iso | eng | ca |
dc.publisher | MDPI | ca |
dc.relation.ispartof | International Journal of Molecular Sciences | ca |
dc.relation.ispartofseries | 21;17 | |
dc.rights | This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | en |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject.other | Angiogènesi | ca |
dc.subject.other | Enginyeria del teixit ossi | ca |
dc.subject.other | Coentrega | ca |
dc.subject.other | Factors de creixement | ca |
dc.subject.other | Multicapa | ca |
dc.subject.other | Osteogènesi | ca |
dc.subject.other | Polidopamina | ca |
dc.subject.other | Bastides | ca |
dc.subject.other | Angiogénesis | es |
dc.subject.other | Ingeniería de tejidos óseos | es |
dc.subject.other | Co-entrega | es |
dc.subject.other | Factores de crecimiento | es |
dc.subject.other | Multicapas | es |
dc.subject.other | Osteogénesis | es |
dc.subject.other | Polidopamina | es |
dc.subject.other | Andamios | es |
dc.subject.other | Angiogenesis | en |
dc.subject.other | Bone tissue engineering | en |
dc.subject.other | Co-delivery | en |
dc.subject.other | Growth factors | en |
dc.subject.other | Multilayers | en |
dc.subject.other | Osteogenesis | en |
dc.subject.other | Polydopamine | en |
dc.subject.other | Scaffolds | en |
dc.title | Immobilization of BMP-2 and VEGF within multilayered polydopamine-coated scaffolds and the resulting osteogenic and angiogenic synergy of co-cultured human mesenchymal stem cells and human endothelial progenitor cells | en |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.subject.udc | 61 | ca |
dc.subject.udc | 616.7 | ca |
dc.identifier.doi | https://dx.doi.org/10.3390/ijms21176418 | ca |
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