Predicting response trajectories during cognitive-behavioural therapy for panic disorder: no association with the BDNF gene or childhood maltreatment
Autor/a
Santacana, Martí
Arias, Bárbara
Mitjans, Marina
Bonillo, Albert
Montoro, María
Rosado, Sílvia
Guillamat, Roser
Vallès, Vicenç
Pérez, Víctor
Forero, Carlos G.
Fullana, Miquel A.
Data de publicació
2016ISSN
1932-6203
Resum
Background: Anxiety disorders are highly prevalent and result in low quality of life and a high social and economic cost. The efficacy of cognitive-behavioural therapy (CBT) for anxiety disorders is well established, but a substantial proportion of patients do not respond to this treatment. Understanding which genetic and environmental factors are responsible for this differential response to treatment is a key step towards “personalized medicine”. Based on previous research, our objective was to test whether the BDNF Val66Met polymorphism and/or childhood maltreatment are associated with response trajectories during exposure-based CBT for panic disorder (PD). Method: We used Growth Mixture Modeling to identify latent classes of change (response trajectories) in patients with PD (N = 97) who underwent group manualized exposure-based CBT. We conducted logistic regression to investigate the effect on these trajectories of the BDNF Val66Met polymorphism and two different types of childhood maltreatment, abuse and neglect. Results: We identified two response trajectories (“high response” and “low response”), and found that they were not significantly associated with either the genetic (BDNF Val66Met polymorphism) or childhood trauma-related variables of interest, nor with an interaction between these variables. Conclusions: We found no evidence to support an effect of the BDNF gene or childhood trauma-related variables on CBT outcome in PD. Future studies in this field may benefit from looking at other genotypes or using different (e.g. whole-genome) approaches.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
English
Matèries (CDU)
159.9 - Psicologia
Paraules clau
Trastorns d’ansietat
Teràpia cognitiu-conductual
TCC
Maltractament infantil
Exposició per al trastorn de pànic
Trastornos de ansiedad
Terapia cognitivo-conductual
TCC
Maltrato infantil
Exposición para el trastorno de pánico
Anxiety disorders
Cognitive-behavioral therapy
TCC
Child abuse
Exposure to panic disorder
Pàgines
14
Publicat per
Public Library of Science
Col·lecció
11; 12
Publicat a
PLoS One
Citació
Santacana, Martí; Arias, Bárbara; Mitjans, Marina [et al.]. Predicting response trajectories during cognitive-behavioural therapy for panic disorder: no association with the BDNF gene or childhood maltreatment. PLoS ONE, 2016, 11(12), e0167833. Disponible en: <https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0158224>. Fecha de acceso: 14 sep. 2021. DOI: 10.1371/journal.pone.0167833
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Drets
© 2016 Santacana et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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