Predicting response trajectories during cognitive-behavioural therapy for panic disorder: no association with the BDNF gene or childhood maltreatment
Author
Santacana, Martí
Arias, Bárbara
Mitjans, Marina
Bonillo, Albert
Montoro, María
Rosado, Sílvia
Guillamat, Roser
Vallès, Vicenç
Pérez, Víctor
Forero, Carlos G.
Fullana, Miquel A.
Publication date
2016ISSN
1932-6203
Abstract
Background: Anxiety disorders are highly prevalent and result in low quality of life and a high social and economic cost. The efficacy of cognitive-behavioural therapy (CBT) for anxiety disorders is well established, but a substantial proportion of patients do not respond to this treatment. Understanding which genetic and environmental factors are responsible for this differential response to treatment is a key step towards “personalized medicine”. Based on previous research, our objective was to test whether the BDNF Val66Met polymorphism and/or childhood maltreatment are associated with response trajectories during exposure-based CBT for panic disorder (PD). Method: We used Growth Mixture Modeling to identify latent classes of change (response trajectories) in patients with PD (N = 97) who underwent group manualized exposure-based CBT. We conducted logistic regression to investigate the effect on these trajectories of the BDNF Val66Met polymorphism and two different types of childhood maltreatment, abuse and neglect. Results: We identified two response trajectories (“high response” and “low response”), and found that they were not significantly associated with either the genetic (BDNF Val66Met polymorphism) or childhood trauma-related variables of interest, nor with an interaction between these variables. Conclusions: We found no evidence to support an effect of the BDNF gene or childhood trauma-related variables on CBT outcome in PD. Future studies in this field may benefit from looking at other genotypes or using different (e.g. whole-genome) approaches.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
159.9 - Psychology
Keywords
Trastorns d’ansietat
Teràpia cognitiu-conductual
TCC
Maltractament infantil
Exposició per al trastorn de pànic
Trastornos de ansiedad
Terapia cognitivo-conductual
TCC
Maltrato infantil
Exposición para el trastorno de pánico
Anxiety disorders
Cognitive-behavioral therapy
TCC
Child abuse
Exposure to panic disorder
Pages
14
Publisher
Public Library of Science
Collection
11; 12
Is part of
PLoS One
Citation
Santacana, Martí; Arias, Bárbara; Mitjans, Marina [et al.]. Predicting response trajectories during cognitive-behavioural therapy for panic disorder: no association with the BDNF gene or childhood maltreatment. PLoS ONE, 2016, 11(12), e0167833. Disponible en: <https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0158224>. Fecha de acceso: 14 sep. 2021. DOI: 10.1371/journal.pone.0167833
This item appears in the following Collection(s)
- Ciències de la Salut [738]
Rights
© 2016 Santacana et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0/