Atypical cyclins: the extended family portrait
Fecha de publicación
2020ISSN
1420-682X
Resumen
Regulation of cell division is orchestrated by cyclins, which bind and activate their catalytic workmates, the cyclin-dependent kinases (CDKs). Cyclins have been traditionally defined by an oscillating (cyclic) pattern of expression and by the presence of a characteristic “cyclin box” that determines binding to the CDKs. Noteworthy, the Human Genome Sequence Project unveiled the existence of several other proteins containing the “cyclin box” domain. These potential “cyclins” have been named new, orphan or atypical, creating a conundrum in cyclins nomenclature. Moreover, although many years have passed after their discovery, the scarcity of information regarding these possible members of the family has hampered the establishment of criteria for systematization. Here, we discuss the criteria that define cyclins and we propose a classification and nomenclature update based on structural features, interactors, and phylogenetic information. The application of these criteria allows to systematically define, for the first time, the subfamily of atypical cyclins and enables the use of a common nomenclature for this extended family.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
English
Materias (CDU)
61 - Medicina
Palabras clave
Fosforilació
Cicle cel·lular
Família de ciclines
Canònic
Transcripcional
Fosforilación
Ciclo celular
Familia ciclina
Canónico
Transcripcional
Phosphorylation
Cell cycle
Cyclin family
Canonical
Transcriptional
Páginas
12
Publicado por
Springer Nature
Colección
77;
Publicado en
Cellular and Molecular Life Sciences
Citación
Quandt Herrera, Eva; Ribeiro, Mariana P. C.; Clotet, Josep. Atypical cyclins: the extended family portrait. Cellular and Molecular Life Sciences, 2020, 77, p. 231-242. Disponible en: <https://link.springer.com/article/10.1007%2Fs00018-019-03262-7>. Fecha de acceso: 13 sep. 2021. DOI: 10.1007/s00018-019-03262-7
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Derechos
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
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