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National cultural dimensions and their impact on construction project management in developing countries: the case of Ghana
(Universiti Sains Malaysia, 2023)
Construction project management (CPM) in developing countries (DCs) tends to experience high levels of failure. These failures have been attributed to technical, behavioural and economic factors. However, ...
Engineered live bacteria suppress Pseudomonas aeruginosa infection in mouse lung and dissolve endotracheal-tube biofilms
(Springer Nature, 2023)
Engineered live bacteria could provide a new modality for treating lung infections, a major cause of mortality worldwide. In the present study, we engineered a genome-reduced human lung bacterium, ...
Spatial control of gene expression by miR319-regulated TCP transcription factors in leaf development
(Oxford University Press, 2018)
The characteristic leaf shapes we see in all plants are in good part the outcome of the combined action of several transcription factor networks that translate into cell division activity during the ...
Improving signal/noise resolution in single-molecule experiments using molecular constructs with short handles
(Elsevier, 2011)
We investigate unfolding/folding force kinetics in DNA hairpins exhibiting two and three states with newly designed short dsDNA handles (29 bp) using optical tweezers. We show how the higher stiffness ...
Engineering a genome-reduced bacterium to eliminate Staphylococcus aureus biofilms in vivo
(EMBO Press, 2021)
Bacteria present a promising delivery system for treating human diseases. Here, we engineered the genome-reduced human lung pathogen Mycoplasma pneumoniae as a live biotherapeutic to treat biofilm-associated ...
Simplified qualitative discrete numerical model to determine cracking pattern in brittle materials by means of finite element method
(Hindawi, 2017)
This paper presents the formulation, implementation, and validation of a simplified qualitative model to determine the crack path of solids considering static loads, infinitesimal strain, and plane ...
Functional characterization of a novel non-coding mutation “Ghent +49A > G” in the iron-responsive element of L-ferritin causing hereditary hyperferritinaemia-cataract syndrome
(Springer Nature, 2017)
Hereditary hyperferritinaemia-cataract syndrome (HHCS) is a rare disorder usually caused by heterozygous mutations in the iron-responsive element (IRE) in the 5′ untranslated region (5′UTR) of the ...
Counter-propagating dual-trap optical tweezers based on linear momentum conservation
(AIP Publishing, 2013)
We present a dual-trap optical tweezers setup which directly measures forces using linear momentum conservation. The setup uses a counter-propagating geometry, which allows momentum measurement on each ...
Unliganded progesterone receptor governs estrogen receptor gene expression by regulating DNA methylation in breast cancer cells
(MDPI, 2018)
Breast cancer prognosis and response to endocrine therapy strongly depends on the expression of the estrogen and progesterone receptors (ER and PR, respectively). Although much is known about ERα gene ...
Measurement of work in single-molecule pulling experiments
(AIP Publishing, 2009)
A main goal of single-molecule experiments is to evaluate equilibrium free energy differences by applying fluctuation relations to repeated work measurements along irreversible processes. We quantify ...