Browsing Ciències Bàsiques by Subject "5"

Now showing items 1-11 of 11

    • comTAR: a web tool for the prediction and characterization of conserved microRNA targets in plants 

      Chorostecki, Uciel; Palatnik, Javier F. (Bioinformatics, 2014)
      Motivation: MicroRNAs (miRNAs) are major regulators of gene expression in plants and animals. They recognize their target messenger RNAs (mRNAs) by sequence complementarity and guide them to cleavage ...

    • Efficiency and precision of microRNA biogenesis modes in plants 

      Moro, Belén; Chorostecki, Uciel; Arikit, Siwaret; Suarez, Irina P.; Höbartner, Claudia; Rasia, Rodolfo M.; Meyers, Blake C.; Palatnik, Javier F. (Nucleic Acids Research, 2018)
      Many evolutionarily conserved microRNAs (miRNAs) in plants regulate transcription factors with key functions in development. Hence, mutations in the core components of the miRNA biogenesis machinery ...

    • Evolutionary footprints reveal insights into plant MicroRNA biogenesis 

      Chorostecki, Uciel; Moro, Belen; Rojas, Arantxa M.L.; Debernardi, Juan M.; Schapire, Arnaldo L.; Notredame, Cedric; Palatnik, Javier F. (The Plant Cell, 2017)
      MicroRNAs (miRNAs) are endogenous small RNAs that recognize target sequences by base complementarity and play a role in the regulation of target gene expression. They are processed from longer precursor ...

    • Identification of key sequence features required for microRNA biogenesis in plants 

      Rojas, Arantxa M. L.; Drusin, Salvador I.; Chorostecki, Uciel; Mateos, Julieta L.; Moro, Belén; Bologna, Nicolas G.; Bresso, Edgardo G.; Schapire, Arnaldo; Rasia, Rodolfo M.; Moreno, Diego M.; Palatnik, Javier F. (Nature Communications, 2020)
      MicroRNAs (miRNAs) are endogenous small RNAs of ∼21 nt that regulate multiple biological pathways in multicellular organisms. They derive from longer transcripts that harbor an imperfect stem-loop ...

    • Identification of new microRNA-regulated genes by conserved targeting in plant species 

      Chorostecki, Uciel; Crosa, Valeria A.; Lodeyro, Anabella F.; Bologna, Nicolás G.; Martin, Ana P.; Carrillo, Néstor; Schommer, Carla; Palatnik, Javier F. (Nucleic Acids Research, 2012)
      MicroRNAs (miRNAs) are major regulators of gene expression in multicellular organisms. They recognize their targets by sequence complementarity and guide them to cleavage or translational arrest. It is ...

    • MetaPhOrs 2.0: integrative, phylogeny-based inference of orthology and paralogy across the tree of life 

      Chorostecki, Uciel; Molina, Manuel; Pryszcz, Leszek P.; Gabaldón, Toni (Nucleic Acids Research, 2020)
      Inferring homology relationships across genes in different species is a central task in comparative genomics. Therefore, a large number of resources and methods have been developed over the years. Some ...

    • Multiple RNA recognition patterns during microRNA biogenesis in plants 

      Bologna, Nicolás G.; Schapire, Arnaldo L.; Zhai, Jixian; Chorostecki, Uciel; Boisbouvier, Jerome; Meyers, Blake C.; Palatnik, Javier F. (Genome Research, 2013)
      MicroRNAs (miRNAs) derive from longer precursors with fold-back structures. While animal miRNA precursors have homogenous structures, plant precursors comprise a collection of fold-backs with variable ...

    • PhylomeDB V5: an expanding repository for genome-wide catalogues of annotated gene phylogenies 

      Fuentes, Diego; Molina, Manuel; Chorostecki, Uciel; Capella-Gutiérrez, Salvador; Marcet-Houben, Marina; Gabaldón, Toni (Nucleic Acids Research, 2022)
      PhylomeDB is a unique knowledge base providing public access to minable and browsable catalogues of pre-computed genome-wide collections of annotated sequences, alignments and phylogenies (i.e. phylomes) ...

    • Spatial control of gene expression by miR319-regulated TCP transcription factors in leaf development 

      Bresso, Edgardo G.; Chorostecki, Uciel; Rodriguez, Ramiro E.; Palatnik, Javier F.; Schommer, Carla (Plant Physiology, 2018)
      The characteristic leaf shapes we see in all plants are in good part the outcome of the combined action of several transcription factor networks that translate into cell division activity during the ...

    • Structural characterization of NORAD reveals a stabilizing role of spacers and two new repeat units 

      Chorostecki, Uciel; Saus, Ester; Gabaldón, Toni (Computational and Structural Biotechnology Journal, 2021)
      Long non-coding RNAs (lncRNAs) can perform a variety of key cellular functions by interacting with proteins and other RNAs. Recent studies have shown that the functions of lncRNAS are largely mediated ...

    • The plant noncoding transcriptome: a versatile environmental sensor 

      Chorostecki, Uciel; Bologna, Nicolas G.; Ariel, Federico (The EMBO Journal, 2023)
      Plant noncoding RNA transcripts have gained increasing attention in recent years due to growing evidence that they can regulate developmental plasticity. In this review article, we comprehensively analyze ...