Now showing items 1-2 of 2

    • ADP-ribose–derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling 

      Wright, Roni; LeDily, Francois; Soronellas, Daniel; Pohl, Andy; Bonet, Jaume; Nacht, A. S.; Vicent, Guillermo Pablo; Wierer, Michael; Oliva, Baldo; Beato, Miguel (Science, 2016)
      Key nuclear processes in eukaryotes, including DNA replication, repair, and gene regulation, require extensive chromatin remodeling catalyzed by energy-consuming enzymes. It remains unclear how the ATP ...
    • Hormone-induced repression of genes requires BRG1-mediated H1.2 deposition at target promoters 

      Nacht, Ana Silvina; Pohl, Andy; Zaurín Quer, Roser; Soronellas, Daniel; Quilez Oliete, Javier; SHARMA, PRIYANKA; Wright, Roni; Beato, Miguel; Vincent, Guillermo P. (The EMBO Journal, 2016)
      Eukaryotic gene regulation is associated with changes in chromatin compaction that modulate access to DNA regulatory sequences relevant for transcriptional activation or repression. Although much is ...