Up-regulation of PARP1 expression significantly correlated with poor survival in mucosal melanomas
Author
Donizy, Piotr
Wu, Cheng-Lin
Mull, Jason
Fujimoto, Masakazu
Chłopik, Agata
Peng, Yan
Shalin, Sara C.
Selim, M. Angelica
Puig, Susana
Fernandez Figueras, Maria-Teresa
Shea, Christopher R.
Biernat, Wojciech
Rys, Janusz
Marszalek, Andrzej
Hoang, Mai P.
Publication date
2020ISSN
2073-4409
Abstract
Introduction: Mucosal melanoma is rare and associated with poorer prognosis in comparison to conventional melanoma subtypes. Little is known about the prognostic significance as well as possible associations between PARP1 and immunologic response in mucosal melanoma. Methods: PARP1, PD-L1 and IDO1 immunostains were performed on 192 mucosal melanomas including 86 vulvar, 89 sinonasal, and 17 anorectal melanomas. Results: By Kaplan–Meier analyses, high PARP1 expression correlated with worse overall and melanoma-specific survival (log-rank p values = 0.026 and 0.047, respectively). Tumors with combined PARP1 and IDO1 high expression correlated with worse overall and melanoma-specific survival (p = 0.015, 0.0034 respectively). By multivariate analyses, high PARP1 expression remained a predictor of worse survival independent of stage. By Fisher’s exact test, high PARP1 expression correlated with highly mitogenic tumors (p = 0.02). High tumoral PD-L1 and IDO1 expression were associated with ulcerated primary tumors (p = 0.019, 0.0019, respectively). By linear regression analyses, correlations between PARP1 expression versus IDO1 expression (p = 0.0001) and mitotic index (p = 0.0052) were observed. Conclusion: Increased expression of PARP1 is an independent negative prognostic marker in mucosal melanomas. The association between PARP1 and IDO1 and their combined adverse prognostic role raise the potential of combined therapy in mucosal melanoma.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
61 - Medical sciences
Keywords
Melanoma de la mucosa
Melanoma vulvar
Melanoma sinonasal
Melanoma anorectal
PARP
IDO1
Pronòstic
Neoplàsia
Melanoma mucoso
Melanoma vulvar
Melanoma nasosinusal
Melanoma anorrectal
PARP
IDO1
Pronóstico
Neoplasia
Mucosal melanoma
Vulvar melanoma
Sinonasal melanoma
Anorectal melanoma
PARP
IDO1
Prognosis
Neoplasia
Pages
12
Publisher
MDPI
Collection
9;5
Is part of
Cells
Citation
Donizy, Piotr; Wu, Cheng-Lin; Mull, Jason [et al.]. Up-regulation of PARP1 expression significantly correlated with poor survival in mucosal melanomas. Cells, 2020, 9(5), 1135. Disponible en: <https://www.mdpi.com/2073-4409/9/5/1135>. Fecha de acceso: 3 sep. 2021. DOI: 10.3390/cells9051135
This item appears in the following Collection(s)
- Ciències de la Salut [725]
Rights
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0/