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Browsing by Subject "PARP"

Now showing items 1-3 of 3

    • The ADP-ribose hydrolase NUDT5 is important for DNA repair 

      Qi, Hongyun; Wright, Roni; Beato, Miguel; Price, Brendan (Cell Reports, 2022-12)
      DNA damage leads to rapid synthesis of poly(ADP-ribose) (pADPr), which is important for damage signaling and repair. pADPr chains are removed by poly(ADP-ribose) glycohydrolase (PARG), releasing free ...

    • Targeting DNA repair defects for precision medicine in prostate cancer 

      Athie, Alejandro; Arce-Gallego, Sara; Gonzalez, Macarena; Morales-Barrera, Rafael; Suarez, Cristina; Casals Galobart, Teresa; Hernandez Viedma, Gonzalo; Carles, Joan; Mateo, Joaquin (Current Oncology Reports, 2019)
      Purpose of Review: Genomic studies of localized and metastatic prostate cancer have identified a high prevalence of clinically actionable alterations including mutations in DNA repair genes. In this ...

    • Up-regulation of PARP1 expression significantly correlated with poor survival in mucosal melanomas 

      Donizy, Piotr; Wu, Cheng-Lin; Mull, Jason; Fujimoto, Masakazu; Chłopik, Agata; Peng, Yan; Shalin, Sara C.; Selim, M. Angelica; Puig, Susana; Fernandez Figueras, Maria-Teresa; Shea, Christopher R.; Biernat, Wojciech; Rys, Janusz; Marszalek, Andrzej; Hoang, Mai P. (Cells, 2020)
      Introduction: Mucosal melanoma is rare and associated with poorer prognosis in comparison to conventional melanoma subtypes. Little is known about the prognostic significance as well as possible ...