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New insights of SF1 neurons in hypothalamic regulation of obesity and diabetes
dc.contributor.author | Fosch, Anna | |
dc.contributor.author | Zagmutt, Sebastián | |
dc.contributor.author | Casals i Farré, Núria | |
dc.contributor.author | Rodríguez-Rodríguez, Rosalía | |
dc.date.accessioned | 2021-06-21T15:58:37Z | |
dc.date.available | 2021-06-21T15:58:37Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Fosch, Anna; Zagmutt, Sebastián; Casals i Farré, Núria [et al.]. New insights of SF1 neurons in hypothalamic regulation of obesity and diabetes. International Journal of Molecular Sciences, 2021, 22(12), 6186. Disponible en: <https://www.mdpi.com/1422-0067/22/12/6186>. Fecha de acceso: 21 jun. 2021. DOI: 10.3390/ijms22126186 | ca |
dc.identifier.issn | 1422-0067 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12328/2644 | |
dc.description.abstract | Despite the substantial role played by the hypothalamus in the regulation of energy balance and glucose homeostasis, the exact mechanisms and neuronal circuits underlying this regulation remain poorly understood. In the last 15 years, investigations using transgenic models, optogenetic, and chemogenetic approaches have revealed that SF1 neurons in the ventromedial hypothalamus are a specific lead in the brain’s ability to sense glucose levels and conduct insulin and leptin signaling in energy expenditure and glucose homeostasis, with minor feeding control. Deletion of hormonal receptors, nutritional sensors, or synaptic receptors in SF1 neurons triggers metabolic alterations mostly appreciated under high-fat feeding, indicating that SF1 neurons are particularly important for metabolic adaptation in the early stages of obesity. Although these studies have provided exciting insight into the implications of hypothalamic SF1 neurons on whole-body energy homeostasis, new questions have arisen from these results. Particularly, the existence of neuronal sub-populations of SF1 neurons and the intricate neurocircuitry linking these neurons with other nuclei and with the periphery. In this review, we address the most relevant studies carried out in SF1 neurons to date, to provide a global view of the central role played by these neurons in the pathogenesis of obesity and diabetes. | en |
dc.format.extent | 22 | ca |
dc.language.iso | eng | ca |
dc.publisher | MDPI | ca |
dc.relation.ispartof | International Journal of Molecular Sciences | ca |
dc.relation.ispartofseries | 22;12 | |
dc.rights | This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | en |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject.other | Neurones SF1 | ca |
dc.subject.other | Nucli hipotàlem ventromedial | ca |
dc.subject.other | Obesitat | ca |
dc.subject.other | Diabetis | ca |
dc.subject.other | Homeòstasi energètica | ca |
dc.subject.other | Homeòstasi de la glucosa | ca |
dc.subject.other | Neuronas SF1 | es |
dc.subject.other | Núcleo del hipotálamo ventromedial | es |
dc.subject.other | Obesidad | es |
dc.subject.other | Diabetes | es |
dc.subject.other | Homeostasis energética | es |
dc.subject.other | Homeostasis de la glucosa | es |
dc.subject.other | SF1 neurons | en |
dc.subject.other | Ventromedial hypothalamus nucleus | en |
dc.subject.other | Obesity | en |
dc.subject.other | Diabetes | en |
dc.subject.other | Energy homeostasis | en |
dc.subject.other | Glucose homeostasis | en |
dc.title | New insights of SF1 neurons in hypothalamic regulation of obesity and diabetes | en |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/2PE/SAF2017-82813-C3-3R | ca |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/2PE/PCI2018-092997/AEI | ca |
dc.subject.udc | 61 | ca |
dc.identifier.doi | https://dx.doi.org/10.3390/ijms22126186 | ca |
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