New insights of SF1 neurons in hypothalamic regulation of obesity and diabetes
Author
Fosch, Anna
Zagmutt, Sebastián
Casals i Farré, Núria
Rodríguez-Rodríguez, Rosalía
Publication date
2021ISSN
1422-0067
Abstract
Despite the substantial role played by the hypothalamus in the regulation of energy balance and glucose homeostasis, the exact mechanisms and neuronal circuits underlying this regulation remain poorly understood. In the last 15 years, investigations using transgenic models, optogenetic, and chemogenetic approaches have revealed that SF1 neurons in the ventromedial hypothalamus are a specific lead in the brain’s ability to sense glucose levels and conduct insulin and leptin signaling in energy expenditure and glucose homeostasis, with minor feeding control. Deletion of hormonal receptors, nutritional sensors, or synaptic receptors in SF1 neurons triggers metabolic alterations mostly appreciated under high-fat feeding, indicating that SF1 neurons are particularly important for metabolic adaptation in the early stages of obesity. Although these studies have provided exciting insight into the implications of hypothalamic SF1 neurons on whole-body energy homeostasis, new questions have arisen from these results. Particularly, the existence of neuronal sub-populations of SF1 neurons and the intricate neurocircuitry linking these neurons with other nuclei and with the periphery. In this review, we address the most relevant studies carried out in SF1 neurons to date, to provide a global view of the central role played by these neurons in the pathogenesis of obesity and diabetes.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
61 - Medical sciences
Keywords
Neurones SF1
Nucli hipotàlem ventromedial
Obesitat
Diabetis
Homeòstasi energètica
Homeòstasi de la glucosa
Neuronas SF1
Núcleo del hipotálamo ventromedial
Obesidad
Diabetes
Homeostasis energética
Homeostasis de la glucosa
SF1 neurons
Ventromedial hypothalamus nucleus
Obesity
Diabetes
Energy homeostasis
Glucose homeostasis
Pages
22
Publisher
MDPI
Collection
22;12
Is part of
International Journal of Molecular Sciences
Citation
Fosch, Anna; Zagmutt, Sebastián; Casals i Farré, Núria [et al.]. New insights of SF1 neurons in hypothalamic regulation of obesity and diabetes. International Journal of Molecular Sciences, 2021, 22(12), 6186. Disponible en: <https://www.mdpi.com/1422-0067/22/12/6186>. Fecha de acceso: 21 jun. 2021. DOI: 10.3390/ijms22126186
Grant agreement number
info:eu-repo/grantAgreement/ES/2PE/SAF2017-82813-C3-3R
info:eu-repo/grantAgreement/ES/2PE/PCI2018-092997/AEI
This item appears in the following Collection(s)
- Ciències de la Salut [712]
Rights
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0/