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Dysregulation of the immune system in HIV/HCV-coinfected patients according to liver stiffness status
dc.contributor.author | Garcia-Broncano, Pilar | |
dc.contributor.author | Medrano, Luz Maria | |
dc.contributor.author | Berenguer, Juan | |
dc.contributor.author | González-García, Juan | |
dc.contributor.author | Jiménez-Sousa, Maria Ángeles | |
dc.contributor.author | Carrero, Ana | |
dc.contributor.author | Hontañón, Víctor | |
dc.contributor.author | Guardiola Tey, Josep Maria | |
dc.contributor.author | Crespo, Manuel | |
dc.contributor.author | Quereda, Carmen | |
dc.contributor.author | Sanz, José | |
dc.contributor.author | García-Gómez, Ana Belen | |
dc.contributor.author | Jimenez, Jose Luis | |
dc.contributor.author | Resino, Salvador | |
dc.contributor.author | GESIDA 3603b Study Group | |
dc.date.accessioned | 2021-06-17T16:45:08Z | |
dc.date.available | 2021-06-17T16:45:08Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Garcia-Broncano, Pilar; Medrano, Luz Maria; Berenguer, Juan [et al.]. Dysregulation of the immune system in HIV/HCV-coinfected patients according to liver stiffness status. Cells, 7(11), 196. Disponible en: <https://www.mdpi.com/2073-4409/7/11/196>. Fecha de acceso: 17 jun, 2021. DOI: 10.3390/cells7110196 | ca |
dc.identifier.issn | 2073-4409 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12328/2636 | |
dc.description.abstract | Background: Advanced cirrhosis is related to alterations in immunity. We aimed to evaluate the levels of peripheral CD4+ T cells (Tregs) and plasma cytokine in patients coinfected with human immunodeficiency virus and hepatitis C virus (HIV/HCV) according to liver fibrosis stages [evaluated as liver stiffness measure (LSM)] and their linear relationship. Methods: We performed a cross-sectional study on 238 HIV/HCV-coinfected patients (119 had <12.5 kPa, 73 had 12.5–25 kPa, and 46 had >25 kPa). Peripheral T-cell subsets were phenotyped by flow cytometry, plasma biomarkers were assessed by multiplex immunoassays, and LSM was assessed by transient elastography. Results: We found HIV/HCV-coinfected patients had higher values of CD4+ Tregs (p < 0.001), memory Tregs (p ≤ 0.001), and plasma cytokine levels [IFN-γ (p ≤ 0.05) and IL-10 (p ≤ 0.01)] compared with healthy donors and HIV-monoinfected patients. In the multivariate analysis, higher LSM values were associated with reduced levels of IL-10 (adjusted arithmetic mean ratio (aAMR) = 0.83; p = 0.019), IL-2 (aAMR = 0.78; p = 0.017), TNF-α (aAMR = 0.67; p < 0.001), and IL-17A (aAMR = 0.75; p = 0.006). When we focus on HIV/HCV-coinfected patients analyzed by LSM strata, patients with ≥25 kPa had lower values of IL-2 (aAMR = 0.66; p = 0.021), TNF-α (aAMR = 0.565; p = 0.003), and IL-17A (aAMR = 0.58; p = 0.003) than patients with <12.5 kPa. Conclusion: HIV/HCV-coinfected patients showed an immunosuppressive profile compared to healthy controls and HIV-monoinfected patients. Additionally, HIV/HCV-coinfected patients with advanced cirrhosis (LSM ≥ 25 kPa) had the lowest plasma values of cytokines related to Th1 (IL-2 and TNF-α) and Th17 (IL-17A) response. | en |
dc.format.extent | 16 | ca |
dc.language.iso | eng | ca |
dc.publisher | MDPI | ca |
dc.relation.ispartof | Cells | ca |
dc.relation.ispartofseries | 7;11 | |
dc.rights | © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open accessarticle distributed under the terms and conditions of the Creative Commons Attribution(CC BY) license (http://creativecommons.org/licenses/by/4.0/). | en |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject.other | Hepatitis C crònica | ca |
dc.subject.other | VIH | ca |
dc.subject.other | Cirrosi | ca |
dc.subject.other | Cèl·lules Treg | ca |
dc.subject.other | Citocines | ca |
dc.subject.other | Disfunció immune | ca |
dc.subject.other | Hepatitis C crónica | es |
dc.subject.other | VIH | es |
dc.subject.other | Cirrosis | es |
dc.subject.other | Células Treg | es |
dc.subject.other | Citocinas | es |
dc.subject.other | Disfunción inmune | es |
dc.subject.other | Chronic hepatitis C. | en |
dc.subject.other | HIV | en |
dc.subject.other | Cirrhosis | en |
dc.subject.other | Treg cells | en |
dc.subject.other | Cytokines | en |
dc.subject.other | Immune dysfunction | en |
dc.title | Dysregulation of the immune system in HIV/HCV-coinfected patients according to liver stiffness status | en |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.subject.udc | 61 | ca |
dc.subject.udc | 616.9 | ca |
dc.identifier.doi | https://dx.doi.org/10.3390/cells7110196 | ca |
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