Dysregulation of the immune system in HIV/HCV-coinfected patients according to liver stiffness status
Autor/a
Garcia-Broncano, Pilar
Medrano, Luz Maria
Berenguer, Juan
González-García, Juan
Jiménez-Sousa, Maria Ángeles
Carrero, Ana
Hontañón, Víctor
Guardiola Tey, Josep Maria
Crespo, Manuel
Quereda, Carmen
Sanz, José
García-Gómez, Ana Belen
Jimenez, Jose Luis
Resino, Salvador
GESIDA 3603b Study Group
Fecha de publicación
2018ISSN
2073-4409
Resumen
Background: Advanced cirrhosis is related to alterations in immunity. We aimed to evaluate the levels of peripheral CD4+ T cells (Tregs) and plasma cytokine in patients coinfected with human immunodeficiency virus and hepatitis C virus (HIV/HCV) according to liver fibrosis stages [evaluated as liver stiffness measure (LSM)] and their linear relationship. Methods: We performed a cross-sectional study on 238 HIV/HCV-coinfected patients (119 had <12.5 kPa, 73 had 12.5–25 kPa, and 46 had >25 kPa). Peripheral T-cell subsets were phenotyped by flow cytometry, plasma biomarkers were assessed by multiplex immunoassays, and LSM was assessed by transient elastography. Results: We found HIV/HCV-coinfected patients had higher values of CD4+ Tregs (p < 0.001), memory Tregs (p ≤ 0.001), and plasma cytokine levels [IFN-γ (p ≤ 0.05) and IL-10 (p ≤ 0.01)] compared with healthy donors and HIV-monoinfected patients. In the multivariate analysis, higher LSM values were associated with reduced levels of IL-10 (adjusted arithmetic mean ratio (aAMR) = 0.83; p = 0.019), IL-2 (aAMR = 0.78; p = 0.017), TNF-α (aAMR = 0.67; p < 0.001), and IL-17A (aAMR = 0.75; p = 0.006). When we focus on HIV/HCV-coinfected patients analyzed by LSM strata, patients with ≥25 kPa had lower values of IL-2 (aAMR = 0.66; p = 0.021), TNF-α (aAMR = 0.565; p = 0.003), and IL-17A (aAMR = 0.58; p = 0.003) than patients with <12.5 kPa. Conclusion: HIV/HCV-coinfected patients showed an immunosuppressive profile compared to healthy controls and HIV-monoinfected patients. Additionally, HIV/HCV-coinfected patients with advanced cirrhosis (LSM ≥ 25 kPa) had the lowest plasma values of cytokines related to Th1 (IL-2 and TNF-α) and Th17 (IL-17A) response.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
English
Materias (CDU)
61 - Medicina
616.9 - Enfermedades infecciosas y contagiosas. Fiebres
Palabras clave
Hepatitis C crònica
VIH
Cirrosi
Cèl·lules Treg
Citocines
Disfunció immune
Hepatitis C crónica
VIH
Cirrosis
Células Treg
Citocinas
Disfunción inmune
Chronic hepatitis C.
HIV
Cirrhosis
Treg cells
Cytokines
Immune dysfunction
Páginas
16
Publicado por
MDPI
Colección
7; 11
Publicado en
Cells
Citación
Garcia-Broncano, Pilar; Medrano, Luz Maria; Berenguer, Juan [et al.]. Dysregulation of the immune system in HIV/HCV-coinfected patients according to liver stiffness status. Cells, 7(11), 196. Disponible en: <https://www.mdpi.com/2073-4409/7/11/196>. Fecha de acceso: 17 jun, 2021. DOI: 10.3390/cells7110196
Este ítem aparece en la(s) siguiente(s) colección(ones)
- Ciències de la Salut [740]
Derechos
© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open accessarticle distributed under the terms and conditions of the Creative Commons Attribution(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Excepto si se señala otra cosa, la licencia del ítem se describe como https://creativecommons.org/licenses/by/4.0/