Asymptomatic carotid atherosclerosis cardiovascular risk factors and common hypertriglyceridemia genetic variants in patients with systemic erythematosus lupus
Autor/a
Fanlo-Maresma, Marta
Candás-Estébanez, Beatriz
Esteve-Luque, Virginia
Padró-Miquel, Ariadna
Escrihuela-Vidal, Francesc
Carratini-Moraes, Monica
Corbella, Emili
Corbella Virós, Xavier
Pintó, Xavier
Data de publicació
2021ISSN
2077-0383
Resum
SLE is associated with increased cardiovascular risk. The objective of this study was to determine the prevalence of asymptomatic carotid atherosclerosis to analyze its relationship with dyslipidemia and related genetic factors in a population of patients with SLE. Seventy-one SLE female patients were recruited. Carotid ultrasound, laboratory profiles, and genetic analysis of the ZPR1, APOA5, and GCKR genes were performed. SLE patients were divided into two groups according to the presence or absence of carotid plaques. Patients with carotid plaque had higher plasma TG (1.5 vs. 0.9 mmol/L, p = 0.001), Non-HDL-C (3.5 vs. 3.1 mmol/L, p = 0.025), and apoB concentrations (1.0 vs. 0.9 g/L, p = 0.010) and a higher prevalence of hypertension (80 vs. 37.5%, p = 0.003) than patients without carotid plaque. The GCKR C-allele was present in 83.3% and 16.7% (p = 0.047) of patients with and without carotid plaque, respectively. The GCKR CC genotype (OR = 0.026; 95% CI: 0.001 to 0.473, p = 0.014), an increase of 1 mmol/L in TG concentrations (OR = 12.550; 95% CI: 1.703 to 92.475, p = 0.013) and to be hypertensive (OR = 9.691; 95% CI: 1.703 to 84.874, p = 0.040) were independently associated with carotid atherosclerosis. In summary, plasma TG concentrations, CGKR CC homozygosity, and hypertension are independent predictors of carotid atherosclerosis in women with SLE.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
English
Matèries (CDU)
61 - Medicina
616.1 - Patologia del sistema circulatori, dels vasos sanguinis. Trastorns cardiovasculars
Paraules clau
Triglicèrids
Aterosclerosi
Lupus eritematós sistèmic
Risc cardiovascular
Aterosclerosi caròtida asimptomàtica
Hipertensió
Dones -- Salut i higiene
Triglicéridos
Aterosclerosis
Lupus eritematoso sistémico
Riesgo cardiovascular
Aterosclerosis carótida asintomática
Hipertensión
Mujeres -- Salud e higiene
Triglycerides
Atherosclerosis
Systemic lupus erythematosus
Cardiovascular risk
Asymptomatic carotid atherosclerosis
Hypertension
Women - Health and hygiene
Pàgines
12
Publicat per
MDPI
Col·lecció
10; 10
Publicat a
Journal of Clinical Medicine
Citació
Fanlo-Maresma, Marta; Candás-Estébanez, Beatriz; Esteve-Luque, Virginia [et al.]. Asymptomatic carotid atherosclerosis cardiovascular risk factors and common hypertriglyceridemia genetic variants in patients with systemic erythematosus lupus. Journal of Clinical Medicine, 2021, 10(10), 2218. Disponible en: <https://www.mdpi.com/2077-0383/10/10/2218>. Fecha de acceso: 7 jun. 2021. DOI: 10.3390/jcm10102218
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Drets
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