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Clinical significance of indeterminate quantiFERON-TB Gold plus assay results in hospitalized COVID-19 patients with severe hyperinflammatory syndrome
dc.contributor.author | Solanich, Xavier | |
dc.contributor.author | Fernández-Huerta, Miguel | |
dc.contributor.author | Basaez, Celeste | |
dc.contributor.author | Antolí, Arnau | |
dc.contributor.author | Rocamora-Blanch, Gemma | |
dc.contributor.author | Corbella Virós, Xavier | |
dc.contributor.author | Santin, Miguel | |
dc.contributor.author | Alcaide, Fernando | |
dc.date.accessioned | 2021-05-31T16:04:26Z | |
dc.date.available | 2021-05-31T16:04:26Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Solanich, Xavier; Fernández-Huerta, Miguel; Basaez, Celeste [et al.]. Clinical significance of indeterminate quantiFERON-TB Gold plus assay results in hospitalized COVID-19 patients with severe hyperinflammatory syndrome. Journal of Clinical Medicine, 2021, 10, 918. Disponible en: <https://www.mdpi.com/2077-0383/10/5/918>. Fecha de acceso: 31 may. 2021. DOI: 10.3390/jcm10050918 | ca |
dc.identifier.issn | 2077-0383 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12328/2570 | |
dc.description.abstract | Performance of the QuantiFERON-TB Gold Plus (QFT-Plus) assay could be affected by conditions of immune dysregulation. Little is known about the reliability of QTF-Plus in COVID-19 patients. Our aim was to determine the prevalence and the factors related to an indeterminate QFT-Plus test in COVID-19 hospitalized patients, and to analyze its relationship with in-hospital mortality. A retrospective analysis of all hospitalized COVID-19 patients on whom a QTF-Plus assay was performed in a tertiary care public hospital during the first epidemic wave in Spain (March–April 2020). Out of a total of 96 patients included, 34 (35.4%) had an indeterminate result, in all cases due to a lack of response in the mitogen control. Factors related to COVID-19 severity, such as higher lactate dehydrogenase (LDH) (odds ratio [OR] 1.005 [95% confidence interval [CI] 1.002–1.008]) and previous administration of corticosteroids (OR 4.477 [95% CI 1.397–14.345]), were independent predictors for indeterminate QFT-Plus assay. Furthermore, indeterminate results were more frequent among COVID-19 patients who died during hospitalization (29.1% vs. 64.7%; p = 0.005). We conclude that QFT-Plus assay yielded an unexpected, high prevalence of indeterminate results in severe COVID-19 patients. Factors related to worse COVID-19 outcome, such as LDH, as well as corticosteroid use before the QFT-Plus assay, seem to be predictors for an indeterminate result. The role of an indeterminate QFT-Plus result in predicting COVID-19 severity and mortality should be evaluated. | en |
dc.format.extent | 8 | ca |
dc.language.iso | eng | ca |
dc.publisher | MDPI | ca |
dc.relation.ispartof | Journal of Clinical Medicine | ca |
dc.relation.ispartofseries | 10; | |
dc.rights | This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | en |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject.other | COVID-19 (Malaltia) | ca |
dc.subject.other | Corticosteroides | ca |
dc.subject.other | Resposta immunitària | ca |
dc.subject.other | COVID-19 | es |
dc.subject.other | Corticosteroides | es |
dc.subject.other | Respuesta inmune | es |
dc.subject.other | COVID-19 | en |
dc.subject.other | Corticosteroids | en |
dc.subject.other | Immune response | en |
dc.title | Clinical significance of indeterminate quantiFERON-TB Gold plus assay results in hospitalized COVID-19 patients with severe hyperinflammatory syndrome | en |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.subject.udc | 61 | ca |
dc.subject.udc | 616.9 | ca |
dc.identifier.doi | https://dx.doi.org/10.3390/jcm10050918 | ca |
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