Clinical significance of indeterminate quantiFERON-TB Gold plus assay results in hospitalized COVID-19 patients with severe hyperinflammatory syndrome
Autor/a
Solanich, Xavier
Fernández-Huerta, Miguel
Basaez, Celeste
Antolí, Arnau
Rocamora-Blanch, Gemma
Corbella Virós, Xavier
Santin, Miguel
Alcaide, Fernando
Fecha de publicación
2021ISSN
2077-0383
Resumen
Performance of the QuantiFERON-TB Gold Plus (QFT-Plus) assay could be affected by conditions of immune dysregulation. Little is known about the reliability of QTF-Plus in COVID-19 patients. Our aim was to determine the prevalence and the factors related to an indeterminate QFT-Plus test in COVID-19 hospitalized patients, and to analyze its relationship with in-hospital mortality. A retrospective analysis of all hospitalized COVID-19 patients on whom a QTF-Plus assay was performed in a tertiary care public hospital during the first epidemic wave in Spain (March–April 2020). Out of a total of 96 patients included, 34 (35.4%) had an indeterminate result, in all cases due to a lack of response in the mitogen control. Factors related to COVID-19 severity, such as higher lactate dehydrogenase (LDH) (odds ratio [OR] 1.005 [95% confidence interval [CI] 1.002–1.008]) and previous administration of corticosteroids (OR 4.477 [95% CI 1.397–14.345]), were independent predictors for indeterminate QFT-Plus assay. Furthermore, indeterminate results were more frequent among COVID-19 patients who died during hospitalization (29.1% vs. 64.7%; p = 0.005). We conclude that QFT-Plus assay yielded an unexpected, high prevalence of indeterminate results in severe COVID-19 patients. Factors related to worse COVID-19 outcome, such as LDH, as well as corticosteroid use before the QFT-Plus assay, seem to be predictors for an indeterminate result. The role of an indeterminate QFT-Plus result in predicting COVID-19 severity and mortality should be evaluated.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
English
Materias (CDU)
61 - Medicina
616.9 - Enfermedades infecciosas y contagiosas. Fiebres
Palabras clave
COVID-19 (Malaltia)
Corticosteroides
Resposta immunitària
COVID-19
Corticosteroides
Respuesta inmune
COVID-19
Corticosteroids
Immune response
Páginas
8
Publicado por
MDPI
Colección
10;
Publicado en
Journal of Clinical Medicine
Citación
Solanich, Xavier; Fernández-Huerta, Miguel; Basaez, Celeste [et al.]. Clinical significance of indeterminate quantiFERON-TB Gold plus assay results in hospitalized COVID-19 patients with severe hyperinflammatory syndrome. Journal of Clinical Medicine, 2021, 10, 918. Disponible en: <https://www.mdpi.com/2077-0383/10/5/918>. Fecha de acceso: 31 may. 2021. DOI: 10.3390/jcm10050918
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