Impact of the 13-valent conjugated pneumococcal vaccine on the direct costs of invasive pneumococcal disease requiring hospital admission in children aged < 5 years: a prospective study
Autor/a
Hernández, Sergi
Navas, Encarna
Aznar-Lou, Ignacio
Ciruela, Pilar
García-García, Juan José
Moraga-Llop, Fernando
Codina, Gemma
De Sevilla, Mariona F.
González-Peris, Sebastià
Esteva, Cristina
Planes, Ana María
Izquierdo, Conchita
Martínez-Osorio, Johanna
Campins, Magda
Uriona, Sonia
Salleras, Luis
Serrano-Blanco, Antoni
Jané, Mireia
Domínguez, Ángela
Fecha de publicación
2020ISSN
2076-393X
Resumen
The lack of invasive pneumococcal disease (IPD) cost studies may underestimate the eect of pneumococcal polysaccharide conjugated vaccines (PCV). The objective of this study was to estimate the direct costs of hospitalized IPD cases. A prospective study was made in children aged <5 years diagnosed with IPD in two high-tech hospitals in Catalonia (Spain) between 2007–2009 (PCV7 period) and 2012–2015 (PCV13 period). Costs were calculated according to 2014 Catalan Health Service rates using diagnostic-related groups. In total, 319 and 154 cases were collected, respectively. Pneumonia had the highest cost (65.7% and 62.0%, respectively), followed by meningitis (25.8% and 26.1%, respectively). During 2007–2015, the costs associated with PCV7 serotypes (Pearson coecient (Pc) = ?0.79; p = 0.036) and additional PCV13 serotypes (Pc = ?0.75; p = 0.05) decreased, but those of other serotypes did not (Pc = 0.23 p = 0.62). The total mean cost of IPD increased in the PCV13 period by 31.4% (¿3016.1 vs. ¿3963.9), mainly due to ICU stay (77.4%; ¿1051.4 vs. ¿1865.6). During the PCV13 period, direct IPD costs decreased due to a reduction in the number of cases, but cases were more severe and had a higher mean cost. During 2015, IPD costs increased due to an increase in the costs associated with non-PCV13 serotypes and serotype 3 and this requires further investigation.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
English
Materias (CDU)
61 - Medicina
Palabras clave
Infants -- Salut i higiene
Vacunes
Pneumococs
Hospitals -- Ingressos i altes
Cost
Niños -- Salud e higiene
Vacunas
Neumococos
Hospitales -- Admisión y alta
Costes
Children -- Health and hygiene
Vaccines
Pneumococcus
Hospitals -- Admissions and discharges
Costs
Páginas
15
Publicado por
MDPI
Colección
8; 3
Publicado en
Vaccines
Citación
Hernández, Sergi; Navas, Encarna; Aznar-Lou, Ignacio [et al.]. Impact of the 13-valent conjugated pneumococcal vaccine on the direct costs of invasive pneumococcal disease requiring hospital admission in children aged < 5 years: a prospective study. Vaccines, 2020, 8(3), 387. Disponible en: <https://www.mdpi.com/2076-393X/8/3/387>. Fecha de acceso: 12 feb. 2021. DOI: 10.3390/vaccines8030387
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© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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