Antibiotic-loaded polypropylene surgical meshes with suitable biological behaviour by plasma functionalization and polymerization
Autor/a
Labay, Cédric Pierre
Canal Arias, José María
Modic, Martina
Cvelbar, Uros
Quiles Pérez, María Teresa
Arbós Vilà, Maria Antonia
Gil Mur, Francisco Javier
Canal Barnils, Cristina
Fecha de publicación
2015-12ISSN
0142-9612
Resumen
Hernia repair is one of the most common operations in general surgery, and its associated complications typically relate to infections, among others. The loading of antibiotics to surgical meshes to deliver them locally in the abdominal hernia repair site can be one way to manage infections associated with surgical implants. However, the amount of drug loaded is restricted by the low wettability of polypropylene (PP). In this work, plasma has been used to tailor the surface properties of PP meshes to obtain high loading of ampicillin while conserving the desired biological properties of the unmodified samples and conferring them with antibacterial activity. It was demonstrated that the new surface chemistry and improved wettability led to 3-fold higher antibiotic loading. Subsequently, a PEG-like dry coating was deposited from tetraglyme with low-pressure plasma which allowed maintaining the high drug loading and kept cell properties such as chemotaxis, adhesion and morphology to the same levels as the untreated ones which have shown long-standing clinical success.
Tipo de documento
Artículo
Versión del documento
Versión aceptada
Lengua
English
Materias (CDU)
61 - Medicina
Palabras clave
Materials biomèdics
Hèrnia inguinal
Polímers
Medicaments
Materiales biomédicos
Hernia inguinal
Polímeros
Medicamentos
Biomedical materials
Inguinal hernia
Polymers
Medications
Páginas
39
Publicado por
Elsevier
Colección
71;
Publicado en
Biomaterials
Citación
Labay, Cédric Pierre; Canal Arias, José María; Modic, Martina [et al.]. Antibiotic-loaded polypropylene surgical meshes with suitable biological behaviour by plasma functionalization and polymerization. Biomaterials, 2015, 71, p. 132-144. Disponible en: <https://www.sciencedirect.com/science/article/pii/S0142961215006894?via%3Dihub>. Fecha de acceso: 8 may. 2020. DOI: 10.1016/j.biomaterials.2015.08.023
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Derechos
© 2015 Elsevier Ltd. All rights reserved.