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dc.contributor.authorLabay, Cédric Pierre
dc.contributor.authorCanal Arias, José María
dc.contributor.authorModic, Martina
dc.contributor.authorCvelbar, Uros
dc.contributor.authorQuiles Pérez, María Teresa
dc.contributor.authorArmengol Carrasco, Manuel
dc.contributor.authorArbós Vilà, Maria Antonia
dc.contributor.authorGil Mur, Francisco Javier
dc.contributor.authorCanal Barnils, Cristina
dc.date.accessioned2020-05-08T14:34:29Z
dc.date.available2020-05-08T14:34:29Z
dc.date.issued2015-12
dc.identifier.citationLabay, Cédric Pierre; Canal Arias, José María; Modic, Martina [et al.]. Antibiotic-loaded polypropylene surgical meshes with suitable biological behaviour by plasma functionalization and polymerization. Biomaterials, 2015, 71, p. 132-144. Disponible en: <https://www.sciencedirect.com/science/article/pii/S0142961215006894?via%3Dihub>. Fecha de acceso: 8 may. 2020. DOI: 10.1016/j.biomaterials.2015.08.023ca
dc.identifier.issn0142-9612ca
dc.identifier.urihttp://hdl.handle.net/20.500.12328/1511
dc.description.abstractHernia repair is one of the most common operations in general surgery, and its associated complications typically relate to infections, among others. The loading of antibiotics to surgical meshes to deliver them locally in the abdominal hernia repair site can be one way to manage infections associated with surgical implants. However, the amount of drug loaded is restricted by the low wettability of polypropylene (PP). In this work, plasma has been used to tailor the surface properties of PP meshes to obtain high loading of ampicillin while conserving the desired biological properties of the unmodified samples and conferring them with antibacterial activity. It was demonstrated that the new surface chemistry and improved wettability led to 3-fold higher antibiotic loading. Subsequently, a PEG-like dry coating was deposited from tetraglyme with low-pressure plasma which allowed maintaining the high drug loading and kept cell properties such as chemotaxis, adhesion and morphology to the same levels as the untreated ones which have shown long-standing clinical success.ca
dc.format.extent39ca
dc.language.isoengca
dc.publisherElsevierca
dc.relation.ispartofBiomaterialsca
dc.relation.ispartofseries71;
dc.rights© 2015 Elsevier Ltd. All rights reserved.ca
dc.subject.otherMaterials biomèdicsca
dc.subject.otherHèrnia inguinalca
dc.subject.otherPolímers
dc.subject.otherMedicaments
dc.subject.otherMateriales biomédicos
dc.subject.otherHernia inguinal
dc.subject.otherPolímeros
dc.subject.otherMedicamentos
dc.subject.otherBiomedical materials
dc.subject.otherInguinal hernia
dc.subject.otherPolymers
dc.subject.otherMedications
dc.titleAntibiotic-loaded polypropylene surgical meshes with suitable biological behaviour by plasma functionalization and polymerizationca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/acceptedVersionca
dc.embargo.termscapca
dc.subject.udc61ca
dc.identifier.doihttp://dx.doi.org/10.1016/j.biomaterials.2015.08.023ca


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