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Pomace olive oil concentrated in triterpenic acids restores vascular function, glucose tolerance and obesity progression in mice
dc.contributor.author | Claro-Cala, Carmen Maria | |
dc.contributor.author | Quintela, Jose Carlos | |
dc.contributor.author | Pérez-Montero, Marta | |
dc.contributor.author | Miñano, Javier | |
dc.contributor.author | Alvarez de Sotomayor, María | |
dc.contributor.author | Dolores Herrera, María | |
dc.contributor.author | Rodríguez-Rodríguez, Rosalía | |
dc.date.accessioned | 2020-03-01T14:59:59Z | |
dc.date.available | 2020-03-01T14:59:59Z | |
dc.date.issued | 2020-01 | |
dc.identifier.citation | Claro-Cala, Carmen Maria; Quintela, Jose Carlos; Pérez-Montero, Marta [et al.]. Pomace olive oil concentrated in triterpenic acids restores vascular function, glucose tolerance and obesity progression in mice. Nutrients, 2020, vol. 12, núm. 2, e323. Disponible en: <https://www.mdpi.com/2072-6643/12/2/323>. Fecha de acceso: 1 mar. 2020. DOI: 10.3390/nu12020323 | ca |
dc.identifier.issn | 2072-6643 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12328/1471 | |
dc.description.abstract | Pomace olive oil, an olive oil sub-product, is a promising source of bioactive triterpenoids such as oleanolic acid and maslinic acid. Considering the vascular actions of pomace olive oil and the potential effects of the isolated oleanolic acid on metabolic complications of obesity, this study investigates for the first time the dietary intervention with a pomace olive oil with high concentrations of the triterpenic acids (POCTA), oleanolic and maslinic acid, during diet-induced obesity in mice. The results demonstrate that obese mice, when switched to a POCTA-diet for 10 weeks, show a substantial reduction of body weight, insulin resistance, adipose tissue inflammation, and particularly, improvement of vascular function despite high caloric intake. This study reveals the potential of a functional food based on pomace olive oil and its triterpenic fraction against obesity progression. Our data also contribute to understanding the health-promoting effects attributable to the Mediterranean diet. | ca |
dc.format.extent | 14 | ca |
dc.language.iso | eng | ca |
dc.publisher | MDPI | ca |
dc.relation.ispartof | Nutrients | ca |
dc.relation.ispartofseries | 12;2 | |
dc.rights | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | ca |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject.other | Obesitat | ca |
dc.subject.other | Metabolisme | |
dc.subject.other | Glucosa | |
dc.subject.other | Dieta | |
dc.subject.other | Insulinoresistència | |
dc.subject.other | Obesity | |
dc.subject.other | Metabolism | |
dc.subject.other | Glucose | |
dc.subject.other | Diet | |
dc.subject.other | Insulin resistance | |
dc.subject.other | Obesidad | |
dc.subject.other | Metabolismo | |
dc.subject.other | Glucosa | |
dc.subject.other | Dieta | |
dc.subject.other | Insulinorresistencia | |
dc.title | Pomace olive oil concentrated in triterpenic acids restores vascular function, glucose tolerance and obesity progression in mice | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/acceptedVersion | ca |
dc.embargo.terms | cap | ca |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/2PE/SAF2017-82813-C3-3-R | ca |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/2PE/PCI2018-092997/AEI | ca |
dc.subject.udc | 61 | ca |
dc.identifier.doi | https://dx.doi.org/10.3390/nu12020323 | ca |
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