Mostra el registre parcial de l'element
A nucleotide-based drug protects against glutamate- and MPP+ -induced neurotoxicity
dc.contributor.author | Gella Concustell, Alejandro | |
dc.contributor.author | Martiáñez Canales, Tània | |
dc.contributor.author | Lamarca Dams, Aloa | |
dc.contributor.author | Gutierrez, Cristina | |
dc.contributor.author | Durany, Nuria | |
dc.contributor.author | Casals i Farré, Núria | |
dc.date.accessioned | 2020-02-22T14:53:56Z | |
dc.date.available | 2020-02-22T14:53:56Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | Gella, Alejandro; Martiañez, Tania; Lamarca, Aloa [et al.]. A nucleotide-based drug protects against glutamate- and MPP+ -induced neurotoxicity. Neuroscience & Medicine, 2011, vol. 2, p. 154-160. Disponible en: <https://www.scirp.org/journal/paperinformation.aspx?paperid=5538>. Fecha de acceso: 22 feb. 2020. DOI: 10.4236/nm.2011.22022 | ca |
dc.identifier.issn | 2158-2912 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12328/1462 | |
dc.description.abstract | Nucleo CMP Forte® is a nucleotide-based drug consisting of cytidinemonophosphate, uridinemonophosphate, uridin-ediphosphate and uridinetriphosphate. It has been prescribed for peripheral nervous system disorders, such as lum-bosciatalgia, diabetic or alcoholic polyneuropathy, or trigeminal neuralgia. Its effects on brain pathologies has re-ceived little attention. We examined its neuroprotective effects on cell toxicity induced by glutamate excitotoxicity or by 1-methyl-4-phenyl-pyridinium (MPP+), an in vitro cell model of Parkinson’s disease. We used the human dopaminergic cell line SH-SY5Y and a primary culture of rat cortical cells pre-treated with the drug for 24 hours and then exposed to MPP+ or glutamate at a range of concentrations. Cell viability was measured at different times. Nucleo CMP Forte® pre-treatment significantly increased the rate of cell division in SH-SY5Y cells, as well as the synthesis of triglycerides and phospholipids. More interestingly, drug pre-treatment significantly reduced MPP+- and glutamate-induced cell death in SH-SY5Y cells and in rat cortical cells. These results indicate that the nucleotides included in Nucleo CMP Forte® are promising therapeutic molecules for the prevention of neuronal death in brain caused by focal ischemia, Parkinson’s disease or other neurodegenerative pathologies. | ca |
dc.format.extent | 7 | ca |
dc.language.iso | eng | ca |
dc.publisher | Scientific Research | ca |
dc.relation.ispartof | Neuroscience & Medicine | ca |
dc.relation.ispartofseries | 2; | |
dc.rights | © 2020 by authors and Scientific Research Publishing Inc. This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License. | ca |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject.other | Nucleòtids | ca |
dc.subject.other | Dany cerebral | |
dc.subject.other | Aminoàcids | |
dc.subject.other | Parkinson, Malaltia de | |
dc.subject.other | Nucleótidos | |
dc.subject.other | Daño cerebral | |
dc.subject.other | Aminoácidos | |
dc.subject.other | Parkinson, Enfermedad de | |
dc.subject.other | Nucleotides | |
dc.subject.other | Brain damage | |
dc.subject.other | Amino acids | |
dc.subject.other | Parkinson's disease | |
dc.title | A nucleotide-based drug protects against glutamate- and MPP+ -induced neurotoxicity | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/acceptedVersion | ca |
dc.embargo.terms | cap | ca |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/1PN/BIO2002-00128 | ca |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/1PN/BIO2005-01591 | ca |
dc.subject.udc | 61 | ca |
dc.identifier.doi | http://dx.doi.org/10.4236/nm.2011.22022 | ca |
Fitxers en aquest element
Aquest element apareix en la col·lecció o col·leccions següent(s)
-
Ciències de la Salut [740]