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    • Differential nasopharyngeal microbiota composition in children according to respiratory health status 

      Henares, Desirée; Brotons de los Reyes, Pedro; de Sevilla, Mariona F; Fernandez-Lopez, Ana; Hernández-Bou, Susanna; Perez-Arguello, Amaresh; Mira, Alex; Muñoz-Almagro, Carmen; Cabrera-Rubio, Raúl (Microbial Genomics, 2021)
      Acute respiratory infections (ARIs) constitute one of the leading causes of antibiotic administration, hospitalization and death among children <5 years old. The upper respiratory tract microbiota has ...

    • Factors associated with depression and anxiety in adults ≥60 years old during the COVID-19 pandemic: a systematic review 

      Ciuffreda, Gianluca; Cabanillas Barea, Sara; Carrasco-Uribarren, Andoni; Albarova-Corral, María Isabel; Argüello-Espinosa, María Irache; Marcén-Román, Yolanda (International Journal of Environmental Research and Public Health, 2021)
      COVID-19 represents a threat to public health and the mental health of the aged population. Prevalence and risk factors of depression and anxiety have been reported in previous reviews in other populations; ...

    • Anthropometric measurements, metabolic profile and physical fitness in a sample of spanish women with type 2 diabetes 

      Lucha López, María Orosia; Vidal-Peracho, Concepcion; Hidalgo-García, César; Rodríguez-Sanz, Jacobo; Tricás-Vidal, Héctor; Hernández-Secorún, Mar; Monti-Ballano, Sofía; Tricás-Moreno, José Miguel; Lucha López, Ana Carmen (International Journal of Environmental Research and Public Health, 2021)
      Background: Exercise training has proven to be effective for treatment of metabolic diseases, such as type 2 diabetes mellitus. The aims of this study were to compare anthropometric measurements, metabolic ...

    • Respiratory physiotherapy interventions used during hospitalization of children and adolescents with asthma 

      Oppermann Ruckert, Daniele; Donadio, Marcio; Heinzmann-Filho, João Paulo (Scientia Medica, 2021)
      Aims: to describe and to compare the airway clearance techniques used for asthma during hospitalization in three pediatric age groups. In addition, we sought to investigate the main reasons for choosing ...

    • Expression of oncogenic drivers in 3D cell culture depends on nuclear ATP synthesis by NUDT5 

      Pickup, Katherine E.; Pardow, Felicitas; Carbonell-Caballero, José; Lioutas, Antonios; Villanueva-Cañas, José Luis; Wright, Roni; Beato, Miguel (Cancers, 2019)
      The growth of cancer cells as oncospheres in three-dimensional (3D) culture provides a robust cell model for understanding cancer progression, as well as for early drug discovery and validation. We have ...

    • Role of the NUDT enzymes in breast cancer 

      Wright, Roni; Beato, Miguel (International Journal of Molecular Sciences, 2021)
      Despite global research efforts, breast cancer remains the leading cause of cancer death in women worldwide. The majority of these deaths are due to metastasis occurring years after the initial treatment ...

    • Antibody conversion rates to SARS-CoV-2 in saliva from children attending summer schools in Barcelona, Spain 

      Dobaño, Carlota; Alonso, Selena; Fernández de Sevilla, Mariona; Vidal, Marta; Jiménez, Alfons; Pons Tomas, Gemma; Jairoce, Chenjerai; Melé Casas, María; Rubio, Rocío; Hernández García, María; Ruiz-Olalla, Gemma; Girona-Alarcón, Mònica; Barrios, Diana; Santano, Rebeca; Mitchell, Robert A.; Puyol, Laura; Mayer, Leonie; Chi, Jordi; Rodrigo Melero, Natalia; Carolis, Carlo; Garcia-Miquel, Aleix; Bonet-Carne, Elisenda; Claverol, Joana; Cubells, Marta; Fortuny, Claudia; Fumado, Vicky; Jou, Cristina; Muñoz-Almagro, Carmen; Izquierdo, Luis; Bassat, Quique; Gratacós, Eduard; Aguilar, Ruth; García-García, Juan José; Moncunill, Gemma; Jordan, Iolanda (BMC Medicine, 2021)
      Background: Surveillance tools to estimate viral transmission dynamics in young populations are essential to guide recommendations for school opening and management during viral epidemics. Ideally, ...

    • Apoyo a la regulación de fumar en el interior de vehículos privados y espacios públicos al aire libre 

      Cartanyà Hueso, Àurea; Lidón-Moyano, Cristina; Fu, Marcela; Ballbè, Montse; Martín-Sánchez, Juan Carlos; González-Marrón, Adrián; Matilla Santander, Nuria; Martínez-Sánchez, Jose M (Revista Española de Salud Pública, 2019)
      Fundamentos: Conocer el apoyo a la regulación del consumo de tabaco es una pieza clave para avanzar en las políticas de control del tabaquismo y reducir la exposición pasiva al tabaco. El objetivo de ...

    • Prevalencia de hogares libres de humo y exposición pasiva al tabaco en población pediátrica (niños de 3 a 36 meses) 

      Díez-Izquierdo, Ana; Cassanello Peñarroya, Pía; Cartanyà-Hueso, Àurea; Matilla-Santander, Nuria; Martínez-Sánchez, José María; Balaguer Santamaría, Albert; Martínez-Sánchez, José María (Revista Española de Salud Pública, 2019)
      Fundamentos: La población pediátrica es la más vulnerable a la exposición pasiva al humo ambiental del tabaco (HAT), siendo los hogares la fuente principal de exposición en niños. El objetivo de este ...

    • Hormone-control regions mediate steroid receptor–dependent genome organization 

      Le Dily, François; Vidal, Enrique; Cuartero, Yasmina; Quilez Oliete, Javier; Nacht, A. Silvina; Vicent, Guillermo P.; Carbonell-Caballero, José; Sharma, Priyanka; Villanueva-Cañas, José Luis; Ferrari, Roberto; De Llobet, Lara Isabel; Verde, Gaetano; Wright, Roni; Beato, Miguel (Genome Research, 2019)
      In breast cancer cells, some topologically associating domains (TADs) behave as hormonal gene regulation units, within which gene transcription is coordinately regulated in response to steroid hormones. ...

    • Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells 

      Page, Brent D.G.; Valerie, Nicholas C.K.; Wright, Roni H.G.; Wallner, Olov; Isaksson, Rebecka; Carter, Megan; Rudd, Sean G.; Loseva, Olga; Jemth, Ann-Sofie; Almlöf, Ingrid; Font-Mateu, Jofre; Llona-Minguez, Sabin; Baranczewski, Pawel; Jeppsson, Fredrik; Homan, Evert; Almqvist, Helena; Axelsson, Hanna; Regmi, Shruti; Gustavsson, Anna-Lena; Lundbäck, Thomas; Scobie, Martin; Strömberg, Kia; Stenmark, Pål; Beato, Miguel; Helleday, Thomas (Nature Communications, 2018)
      With a diverse network of substrates, NUDIX hydrolases have emerged as a key family of nucleotide-metabolizing enzymes. NUDT5 (also called NUDIX5) has been implicated in ADP-ribose and 8-oxo-guanine ...

    • Distinct structural transitions of chromatin topological domains correlate with coordinated hormone-induced gene regulation 

      Le Dily, François; Bau, Davide; Pohl, Andy; Vicent, Guillermo P.; Serra, Francois; Soronellas, Daniel; Castellano, Giancarlo; Wright, Roni; Ballare, Cecilia; Filion, Guillaume; Marti-Renom, Marc A.; Beato, Miguel (Genes & Development, 2014)
      The human genome is segmented into topologically associating domains (TADs), but the role of this conserved organization during transient changes in gene expression is not known. Here we describe the ...

    • MyoD induces ARTD1 and nucleoplasmic poly-ADP-ribosylation during fibroblast to myoblast transdifferentiation 

      Bisceglie, Lavinia; Hopp, Ann-Katrin; Gunasekera, Kapila; Wright, Roni; Le Dily, François; Vidal, Enrique; Dall'Agnese, Alessandra; Caputo, Luca; Nicoletti, Chiara; Puri, Pier Lorenzo; Beato, Miguel; Hottiger, Michael O. (iScience, 2021)
      While protein ADP-ribosylation was reported to regulate differentiation and dedifferentiation, it has so far not been studied during transdifferentiation. Here, we found that MyoD-induced transdifferentiation ...

    • 90 years of progesterone: molecular mechanisms of progesterone receptor action on the breast cancer genome 

      Beato, Miguel; Wright, Roni; Le Dily, François (Journal of Molecular Endocrinology, 2020)
      Gene regulation by steroid hormones has been at the forefront in elucidating the intricacies of transcriptional regulation in eukaryotes ever since the discovery by Karlson and Clever that the insect ...

    • Signalling network of breast cancer cells in response to progesterone 

      Wright, Roni; Vastolo, Viviana; Quilez, Javier; Carbonell Caballero, José; Beato, Miguel (BioRxiv, 2020)
      Breast cancer cells enter into the cell cycle following progestin exposure by the activation of signalling cascades involving a plethora of enzymes, transcription factors and co-factors that transmit ...

    • Plataformas digitales y empleo: necesidad de monitorización y vigilancia de Salud Pública 

      Matilla Santander, Nuria; Martínez-Sánchez, José María (Revista Española de Salud Publica, 2018)
      Actualmente, la relación entre las condiciones del trabajo y empleo con la salud es bien conocida, además esta relación es un importante determinante social de la salud de la población trabajadora ...

    • Sarampión en Europa: necesidad de acción global y local para su erradicación 

      González-Marrón, Adrián; Martínez-Sánchez, José María (Gaceta Sanitaria, 2018)
      Uno de los objetivos actuales de la Organización Mundial de la Salud (OMS) es la erradicación del sarampión y la rubéola en al menos cinco regiones de la OMS para el año 2020, como se recoge en el Plan ...

    • Two opposing faces of retinoic acid: induction of stemness or induction of differentiation depending on cell-type 

      Mezquita, Belén; Mezquita , Cristobal (Biomolecules, 2019)
      Stem cells have the capacity of self-renewal and, through proliferation and differentiation, are responsible for the embryonic development, postnatal development, and the regeneration of tissues in the ...

    • Polyphosphate degradation by Nudt3-Zn2+ mediates oxidative stress response 

      Samper Martín, Bàrbara; Sarrias, Ana; Lázaro, Blanca; Pérez-Montero, Marta; Rodríguez-Rodríguez, Rosalía; P.C. Ribeiro, Mariana; Bañón, Aitor; Wolfgeher, Donald; Jessen, Henning J.; Alsina, Berta; Clotet Erra, Josep; Kron, Stephen J.; Saiardi, Adolfo; Jiménez, Javier; Bru Rullo, Samuel (Cell Reports, 2021)
      Polyphosphate (polyP) is a polymer of hundreds of phosphate residues present in all organisms. In mammals, polyP is involved in crucial physiological processes, including coagulation, inflammation, and ...

    • Correlation between tobacco control policies and mortality of haematological cancers across Europe: an ecological study 

      Mehta, Dipal; Dennis, Rory; Nallamilli, Susanna; Vithayathil, Mathew; Martínez Sánchez, Jose María (Tobacco, Prevention & Cessation, 2021)
      Introduction: To determine the correlation between tobacco control policies and mortality of haematological malignancies: leukemia, lymphoma and multiple myeloma (MM). Methods: Ecological study with the ...