Ciències de la Salut: Enviaments recents
Ara mostrant els elements 941-960 de 1006
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The impact of KRAS mutations on VEGF-A production and tumour vascular network
(BMC Cancer, 2013-03-18)Background: The malignant potential of tumour cells may be influenced by the molecular nature of KRAS mutations being codon 13 mutations less aggressive than codon 12 ones. Their metabolic profile is ... -
Impaired cerebral autoregulation is associated with brain dysfunction in patients with sepsis
(Critical Care, 2018-12-04)Background: Sepsis-associated brain dysfunction (SABD) is associated with high morbidity and mortality. The pathophysiology of SABD is multifactorial. One hypothesis is that impaired cerebral autoregulation ... -
Predicting patient-ventilator asynchronies with hidden markov models
(Scientific Reports, 2018-12-04)In mechanical ventilation, it is paramount to ensure the patient’s ventilatory demand is met while minimizing asynchronies. We aimed to develop a model to predict the likelihood of asynchronies occurring. ... -
High red blood cell distribution width as a marker of hospital mortality after ICU discharge: a cohort study
(Journal of Intensive Care, 2018-11-16)Background: High red blood cell distribution width (RDW) is associated with worse outcome in diverse scenarios, including in critical illness. The Sabadell score (SS) predicts in-hospital survival after ... -
Central ceramide-induced hypothalamic lipotoxicity and ER stress regulate energy balance
(Cell Reports, 2014-10)Hypothalamic endoplasmic reticulum (ER) stress is a key mechanism leading to obesity. Here, we demonstrate that ceramides induce lipotoxicity and hypothalamic ER stress, leading to sympathetic inhibition, ... -
CPT1C in the ventromedial nucleus of the hypothalamus is necessary for brown fat thermogenesis activation in obesity
(Molecular Metabolism, 2019-01)Objective: Carnitine palmitoyltransferase 1C (CPT1C) is implicated in central regulation of energy homeostasis. Our aim was to investigate whether CPT1C in the ventromedial nucleus of the hypothalamus ... -
Astrocytes and oligodendrocytes in grey and white matter regions of the brain metabolize fatty acids
(Scientific Reports, 2017-09-07)The grey and white matter regions of the mammalian brain consist of both neurons and neuroglial cells. Among the neuroglia, the two macroglia oligodendrocytes and astrocytes are the most abundant cell ... -
Increased infammation, oxidative stress and mitochondrial respiration in brown adipose tissue from obese mice
(Scientific Reports, 2017-11-22)Obesity is associated with severe metabolic diseases such as type 2 diabetes, insulin resistance, cardiovascular disease and some forms of cancer. The pathophysiology of obesity-induced metabolic diseases ... -
Uridine 5'-triphosphate promotes in vitro Schwannoma cell migration through matrix metalloproteinase-2 activation
(PLoS One, 2014-06-06)In response to peripheral nerve injury, Schwann cells adopt a migratory phenotype and modify the extracellular matrix to make it permissive for cell migration and axonal re-growth. Uridine 5′-triphosphate ... -
Increasing Cervical Cancer Screening Coverage: A Randomised, Community-Based Clinical Trial
(PLoS One, 2017-01-24)Background: Opportunistic cervical cancer screening can lead to suboptimal screening coverage. Coverage could be increased after a personalised invitation to the target population. We present a community ... -
What attributes should be included in a discrete choice experiment related to health technologies? A systematic literature review
(PLoS One, 2019-07-18)Discrete choice experiments (DCEs) are a way to assess priority-setting in health care provision. This approach allows for the evaluation of individuals’ preferences as a means of adding criteria to ... -
Functional massage of the teres major muscle in patients with subacromial impingement syndrome: a randomized controlled case series study
(International Journal of Medical and Pharmaceutical Case Reports, 2016)Objective: the purpose of the present study was to analyze the concurrent validity and reliability of a force platform clinical COBS Feedback® for the estimation of the height of vertical jumps. Design: ... -
Validation of walking trails for the urban training of chronic obstructive pulmonary disease patients
(PLoS ONE, 2016-01-14)Purpose: Accessible interventions to train patients with chronic obstructive pulmonary disease (COPD) are needed. We designed urban trails of different intensities (low, moderate and high) in different ... -
Determinants of study completion and response to a 12-month behavioral physical activity intervention in chronic obstructive pulmonary disease: a cohort study
(PLoS ONE, 2019-05-20)Objectives: Physical activity is key to improve the prognosis of chronic obstructive pulmonary disease (COPD). To help to tailor future interventions we aimed to identify the baseline characteristics ... -
Alternatives to conventional hospitalization for improving lack of access to inpatient beds: a 12-year cross-sectional analysis
(Journal of Hospital Administration, 2013-12-17)Background/Objective: When hospitals cannot guarantee available hospital beds for inpatient admission, patients are exposed to prolonged waits, cancellations and diversions that negatively affect their ... -
Survival benefit of multidisciplinary care in amyotrophic lateral sclerosis in Spain: association with noninvasive mechanical ventilation
(Journal of Multidisciplinary Healthcare, 2019)Purpose: Multidisciplinary care has become the preferred model of care for patients with amyotrophic lateral sclerosis (ALS). It is assumed that the sum of interventions associated with this approach ... -
MMPs/TIMPs and inflammatory signalling de‐regulation in human incisional hernia tissues
(Journal of Cellular and Molecular Medicine, 2009-03-04)Incisional hernia is a common and important complication of laparotomies. Epidemiological studies allude to an underlying biological cause, at least in a subset of population. Interest has mainly focused ... -
Induction of ER stress in response to oxygen-glucose deprivation of cortical cultures involves the activation of the PERK and IRE-1 pathways and of caspase-12
(Cell Death and Disease, 2011-04-28)Disturbance of calcium homeostasis and accumulation of misfolded proteins in the endoplasmic reticulum (ER) are considered contributory components of cell death after ischemia. However, the signal-transducing ... -
In vivo osteogenic potential of biomimetic hydroxyapatite/collagen microspheres: comparison with injectable cement pastes
(PLoS One, 2015-07-01)The osteogenic capacity of biomimetic calcium deficient hydroxyapatite microspheres with and without collagen obtained by emulsification of a calcium phosphate cement paste has been evaluated in an in ... -
Proteostasis collapse, a hallmark of aging, hinders the chaperone-Start network and arrests cells in G1
(eLife, 2019-09-13)Loss of proteostasis and cellular senescence are key hallmarks of aging, but direct cause-effect relationships are not well understood. We show that most yeast cells arrest in G1 before death with low ...