Ciències de la Salut: Enviaments recents
Ara mostrant els elements 601-620 de 1006
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Limited joint mobility progression in type 1 diabetes: a 15-year follow-up study
(International Journal of Endocrinology, 2018)Objective. To assess the evolution of joint mobility over a period of 15 years in type 1 diabetic patients and healthy controls and to determine whether microalbuminuria is associated with a different ... -
Machine learning to understand the immune-inflammatory pathways in fibromyalgia
(International Journal of Molecular Sciences, 2019)Fibromyalgia (FM) is a chronic syndrome characterized by widespread musculoskeletal pain, and physical and emotional symptoms. Although its pathophysiology is largely unknown, immune-inflammatory pathways ... -
Functional consequences of transferrin receptor-2 mutations causing hereditary hemochromatosis type 3
(Molecular Genetics & Genomic Medicine, 2015)Hereditary hemochromatosis (HH) type 3 is an autosomal recessive disorder of iron metabolism characterized by excessive iron deposition in the liver and caused by mutations in the transferrin receptor ... -
Comparing infant and toddler sleep patterns prior to and during the first wave of home confinement due to COVID-19 in Spain
(European Journal of Pediatrics, 2022)Recent literature has shown that sleep patterns are shaped during the first years of life, playing a relevant role in children’s functioning. We focused on comparing sleep patterns in infants and toddlers ... -
Serotypes and clonal composition of streptococcus pneumoniae isolates causing IPD in children and adults in Catalonia before 2013 to 2015 and after 2017 to 2019 systematic introduction of PCV13
(Microbiology Spectrum, 2021)The goal of this study was to investigate the distribution of serotypes and clonal composition of Streptococcus pneumoniae isolates causing invasive pneumococcal disease (IPD) in Catalonia, before and ... -
Implementing technology in healthcare: insights from physicians
(BMC Medical Informatics and Decision Making, 2017)Background: Technology has significantly changed the way health organizations operate. However, the role it plays in healthcare systems remains unclear. This aim of this study was to evaluate the opinion ... -
Novel mutations in the ferritin-L iron-responsive element that only mildly impair IRP binding cause hereditary hyperferritinaemia cataract syndrome
(Orphanet Journal of Rare Diseases, 2013)Background: Hereditary Hyperferritinaemia Cataract Syndrome (HHCS) is a rare autosomal dominant disease characterized by increased serum ferritin levels and early onset of bilateral cataract. The disease ... -
SIREs: searching for iron-responsive elements
(Nucleic Acids Research, 2010-07)The iron regulatory protein/iron-responsive element regulatory system plays a crucial role in the post-transcriptional regulation of gene expression and its disruption results in human disease. IREs are ... -
The IronChip evaluation package: a package of perl modules for robust analysis of custom microarrays
(BMC Bioinformatics, 2010)Background: Gene expression studies greatly contribute to our understanding of complex relationships in gene regulatory networks. However, the complexity of array design, production and manipulations ... -
Genetic and clinical heterogeneity in thirteen new cases with aceruloplasminemia. Atypical anemia as a clue for an early diagnosis
(International Journal of Molecular Sciences, 2020)Aceruloplasminemia is a rare autosomal recessive genetic disease characterized by mild microcytic anemia, diabetes, retinopathy, liver disease, and progressive neurological symptoms due to iron accumulation ... -
CoDysAn: a telemedicine tool to improve awareness and diagnosis for patients with congenital dyserythropoietic anemia
(Frontiers in Physiology, 2019)Congenital Dyserythropoietic Anemia (CDA) is a heterogeneous group of hematological disorders characterized by chronic hyporegenerative anemia and distinct morphological abnormalities of erythroid ... -
Molecular evolution of multiple-level control of heme biosynthesis pathway in animal kingdom
(PLoS One, 2014)Adaptation of enzymes in a metabolic pathway can occur not only through changes in amino acid sequences but also through variations in transcriptional activation, mRNA splicing and mRNA translation. The ... -
L-ferritin: one gene, five diseases; from hereditary hyperferritinemia to hypoferritinemia - report of new cases
(Pharmaceuticals, 2019)Ferritin is a multimeric protein composed of light (L-ferritin) and heavy (H-ferritin) subunits that binds and stores iron inside the cell. A variety of mutations have been reported in the L-ferritin ... -
Factors associated with depression and anxiety in adults ≥60 tears old during the COVID-19 pandemic: a systematic review
(International Journal of Environmental Research and Public Health, 2021)COVID-19 represents a threat to public health and the mental health of the aged population. Prevalence and risk factors of depression and anxiety have been reported in previous reviews in other populations; ... -
Covid-19, an opportunity to compare in-person and online teaching
(Revista Española de Educación Médica, 2021)For years it has been discussed the dichotomy between traditional in-person teaching versus online instruction. The lockdown, consequence of the Covid-19 pandemic, gave us an opportunity to gain evidence ... -
Immobilization of BMP-2 and VEGF within multilayered polydopamine-coated scaffolds and the resulting osteogenic and angiogenic synergy of co-cultured human mesenchymal stem cells and human endothelial progenitor cells
(International Journal of Molecular Sciences, 2020)We have previously reported the fabrication of a polycaprolactone and hydroxyapatite composite scaffold incorporating growth factors to be used for bone regeneration. Two growth factors were incorporated ... -
New mutations in HFE2 and TFR2 genes causing non HFE-related hereditary hemochromatosis
(Genes, 2021)Hereditary hemochromatosis (HH) is an iron metabolism disease clinically characterized by excessive iron deposition in parenchymal organs such as liver, heart, pancreas, and joints. It is caused by ... -
¿Qué hemos aprendido de las encuestas de la AEC, AECP y del Observatorio de Infección en Cirugía? Cumplimiento de las medidas de prevención de infección postoperatoria y comparación con las recomendaciones de la AEC
(Cirugía Española, 2021)Antes de planificar estrategias de mejora, es crucial conocer el grado de implementación de las medidas preventivas de infección postoperatoria. Se presentan los resultados agregados de 3 encuestas ... -
Surgeon-led 7-VINCut antibiotic stewardship intervention decreases duration of treatment and carbapenem use in a general surgery service
(Antibiotics, 2021)Antibiotic stewardship programs optimize the use of antimicrobials to prevent the development of resistance and improve patient outcomes. In this prospective interventional study, a multidisciplinary ... -
Oral antibiotic prophylaxis lowers surgical site infection in elective colorectal surgery: results of a pragmatic cohort study in Catalonia
(Journal of Clinical Medicine, 2021)Background: The role of oral antibiotic prophylaxis (OAP) and mechanical bowel preparation (MBP) in the prevention of surgical site infection (SSI) after colorectal surgery is still controversial. The ...