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Cpt1c downregulation causes plasma membrane remodelling and anthracycline resistance in breast cancer
(MDPI, 2023)
Breast cancer (BC) is the most common malignancy in women worldwide. While the main systemic treatment option is anthracycline-containing chemotherapy, chemoresistance continues to be an obstacle to ...
Determinants of depressive symptoms in people living with HIV: findings from a population-based study with a gender perspective
(MDPI, 2023)
Depressive symptoms are common among people living with HIV (PLWH). The aim of this study was to identify the determinants of depressive symptoms in PLWH in Spain. A total of 1060 PLWH participated in ...
Impact of the bacterial nasopharyngeal microbiota on the severity of genus enterovirus lower respiratory tract infection in children: a case–control study
(John Wiley & Sons, 2023)
Introduction: Rhinoviruses (RV) and enteroviruses (EV) are among the main causative etiologies of lower respiratory tract infection (LRTI) in children. The clinical spectrum of RV/EV infection is wide, ...
Tobacco smoke is not limited to second hand smoke
(The Lancet, 2023)
We read with interest “Thirdhand Smoke Exposure Induces Oxidative Damage, Initiates Skin Inflammatory Disease, and Adversely Alters the Human Plasma Proteome” by Sakamaki-Ching et al.,1 which is reported ...
A novel device for assessment and treatment of upper cervical spine: test–retest reliability study
(MDPI, 2023)
Introduction: Neck pain is one of the most frequent reasons for consultation in primary care. Clinicians evaluate different variables, including movement and cervical strength, to determine the prognosis ...
Variation in nicotine metabolization according to biological factors and type of nicotine consumer
(MDPI, 2023)
This study aims to describe the nicotine metabolite ratio among tobacco smokers and electronic cigarette (e-cigarette) users and nonusers. We analyzed pooled data from a longitudinal and a cross-sectional ...
Central regulation of brown fat thermogenesis in response to saturated or unsaturated long-chain fatty acids
(MDPI, 2023)
Sensing of long-chain fatty acids (LCFA) in the hypothalamus modulates energy balance, and its disruption leads to obesity. To date, the effects of saturated or unsaturated LCFA on hypothalamic-brown ...
Optimized metrics for orthogonal combinatorial CRISPR screens
(Springer Nature, 2023)
CRISPR-based gene perturbation enables unbiased investigations of single and combinatorial genotype-to-phenotype associations. In light of efforts to map combinatorial gene dependencies at scale, choosing ...
Evaluation of plasma lipocalin-2 as a predictor of etiology and severity in adult patients with community-acquired pneumonia
(MDPI, 2023)
The aim of this study was to evaluate the diagnostic performance of plasma Lipocalin-2 (LCN2) concentration in adult patients with community-acquired pneumonia (CAP) to determine its etiology, severity ...
Physical and mental health impact of the COVID-19 pandemic at first year in a Spanish adult cohort
(MDPI, 2023)
The COVID-19 pandemic and the political and health measures have profoundly affected the health of our populations. However, very few studies have been published assessing its impact using a prospective ...