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Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells
(Springer Nature, 2018)
With a diverse network of substrates, NUDIX hydrolases have emerged as a key family of nucleotide-metabolizing enzymes. NUDT5 (also called NUDIX5) has been implicated in ADP-ribose and 8-oxo-guanine ...
Apoyo a la regulación de fumar en el interior de vehículos privados y espacios públicos al aire libre
(Ministerio de Sanidad, Consumo y Bienestar Social, 2019)
Fundamentos: Conocer el apoyo a la regulación del consumo de tabaco es una pieza clave para avanzar en las políticas de control del tabaquismo y reducir la exposición pasiva al tabaco. El objetivo de ...
A social return on investment analysis of improving the management of chronic obstructive pulmonary disease within the spanish national healthcare system
(Dove Press, 2022)
Purpose: To define a set of proposals that would improve the current management of chronic obstructive pulmonary disease (COPD) within the Spanish National Healthcare System (SNHS) from a comprehensive ...
Association of sleep disorders with heart rate variability in children and adolescents with cystic fibrosis
(Zeppelini Publishers, 2022)
Objective: To assess the association of sleep disorders with the findings of heart rate variability (HRV) in children and adolescents with cystic fibrosis (CF). Methods: Cross-sectional study including ...
Effects and safety of hypertonic saline combined with airway clearance in non-hospitalized children with recurrent wheezing
(World Scientific Publishing, 2023)
Background: The International Study of Wheezing in Infants defines recurrent wheezing as the presence of three or more medically documented episodes of wheezing within one year. To date, there is no ...
Fructose-1,6-bisphosphate prevents pulmonary fibrosis by regulating extracellular matrix deposition and inducing phenotype reversal of lung myofibroblasts
(Public Library of Science, 2019)
Pulmonary fibrosis (PF) is the result of chronic injury where fibroblasts become activated and secrete large amounts of extracellular matrix (ECM), leading to impaired fibroblasts degradation followed ...
Effects of using the surgical mask and FFP2 during the 6-min walking test. A randomized controlled trial
(MDPI, 2021)
During the COVID-19 pandemic, the use of masks has been recommended as a containment measure. The mask is a hindrance to normal breathing that causes discomfort. This could put more work on the respiratory ...
Effects of a short-term resistance-training program on heart rate variability in children with cystic fibrosis: a randomized controlled trial
(Frontiers Media, 2021)
Background: Cystic fibrosis (CF) affects the autonomic nervous system (ANS) and exercise in healthy children modulates the interaction between sympathetic and parasympathetic activity. This study aimed ...
Safety and efficacy of devices delivering Inhaled antibiotics among adults with non-cystic fibrosis bronchiectasis: a systematic review and a network meta-analysis
(MDPI, 2022)
It remains unknown whether the type of aerosol generating device is affecting efficacy and safety among non-cystic fibrosis bronchiectasis (NCFB) adults. The proposal of this network meta-analysis (NMA) ...
Related factors to streptococcus pneumoniae invasive infection and clinical manifestations: the potential role of nasopharyngeal microbiome
(Frontiers Media, 2021-04)
Infections of the lower respiratory tract, such as pneumonia, are one of the leading causes of death worldwide. Streptococcus pneumoniae might colonize the upper respiratory tract and is the main ...