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Role of the NUDT enzymes in breast cancer
(MDPI, 2021)
Despite global research efforts, breast cancer remains the leading cause of cancer death in women worldwide. The majority of these deaths are due to metastasis occurring years after the initial treatment ...
Expression of oncogenic drivers in 3D cell culture depends on nuclear ATP synthesis by NUDT5
(MDPI, 2019)
The growth of cancer cells as oncospheres in three-dimensional (3D) culture provides a robust cell model for understanding cancer progression, as well as for early drug discovery and validation. We have ...
Signalling network of breast cancer cells in response to progesterone
(Cold Spring Harbor Laboratory, 2020)
Breast cancer cells enter into the cell cycle following progestin exposure by the activation of signalling cascades involving a plethora of enzymes, transcription factors and co-factors that transmit ...
90 years of progesterone: molecular mechanisms of progesterone receptor action on the breast cancer genome
(Bioscientifica Ltd., 2020)
Gene regulation by steroid hormones has been at the forefront in elucidating the intricacies of transcriptional regulation in eukaryotes ever since the discovery by Karlson and Clever that the insect ...
Hormone-control regions mediate steroid receptor–dependent genome organization
(Cold Spring Harbor Laboratory Press, 2019)
In breast cancer cells, some topologically associating domains (TADs) behave as hormonal gene regulation units, within which gene transcription is coordinately regulated in response to steroid hormones. ...