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Polyphosphate degradation by Nudt3-Zn2+ mediates oxidative stress response
(Elsevier, 2021)
Polyphosphate (polyP) is a polymer of hundreds of phosphate residues present in all organisms. In mammals, polyP is involved in crucial physiological processes, including coagulation, inflammation, and ...
The quantitative changes in the yeast Hsp70 and Hsp90 interactomes upon DNA damage
(Elsevier, 2015-03)
The molecular chaperones Hsp70 and Hsp90 participate in many important cellular processes, including how cells respond to DNA damage. Here we show the results of applied quantitative affinity-purification ...
The atypical cyclin CNTD2 promotes colon cancer cell proliferation and migration
(Scientific Reports, 2018-08-07)
Colorectal cancer (CRC) is one of the most common cancers worldwide, with 8–10% of these tumours presenting a BRAF (V600E) mutation. Cyclins are known oncogenes deregulated in many cancers, but the role ...
A systematic analysis of orphan cyclins reveals CNTD2 as a new oncogenic driver in lung cancer
(Scientific Reports, 2017-08-31)
As lung cancer has increased to the most common cause of cancer death worldwide, prognostic
biomarkers and efective targeted treatments remain lacking despite advances based on patients’
stratifcation. ...
Phosphoregulation of the oncogenic protein regulator of cytokinesis 1 (PRC1) by the atypical CDK16/CCNY complex
(Experimental and molecular medicine, 2019)
CDK16 (also known as PCTAIRE1 or PCTK1) is an atypical member of the cyclin-dependent kinase (CDK) family that forms an active complex with cyclin Y (CCNY). Although both proteins have been recently ...