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Mad3 modulates the G1 Cdk and acts as a timer in the Start network
(American Association for the Advancement of Science, 2022)
Cells maintain their size within limits over successive generations to maximize fitness and survival. Sizer, timer, and adder behaviors have been proposed as possible alternatives to coordinate growth ...
Growth rate as a direct regulator of the start network to set cell size
(Frontiers Media, 2017-05-26)
Cells are able to adjust their growth and size to external inputs to comply with specific
fates and developmental programs. Molecular pathways controlling growth also have
an enormous impact in cell ...
Nucleosome architecture throughout the cell cycle
(Nature Research, 2016-01-28)
Nucleosomes provide additional regulatory mechanisms to transcription and DNA replication
by mediating the access of proteins to DNA. During the cell cycle chromatin undergoes several
conformational ...
Centromeric signaling proteins boost G1 cyclin degradation and modulate cell size in budding yeast
(Public Library of Science, 2018-08-06)
Cell size scales with ploidy in a great range of eukaryotes, but the underlying mechanisms
remain unknown. Using various orthogonal single-cell approaches, we show that cell size
increases linearly ...
Competition in the chaperone-client network subordinates cell-cycle entry to growth and stress
(Life Science Alliance, 2019-04-15)
The precise coordination of growth and proliferation has a
universal prevalence in cell homeostasis. As a prominent
property, cell size is modulated by the coordination between
these processes in ...
The critical size is set at a single-cell level by growth rate to attain homeostasis and adaptation
(Nature Research, 2012-08-21)
Budding yeast cells are assumed to trigger Start and enter the cell cycle only after they attain a critical size set by external conditions. However, arguing against deterministic models of cell size ...
Proteostasis collapse, a hallmark of aging, hinders the chaperone-Start network and arrests cells in G1
(eLife Sciences Publications, 2019-09-13)
Loss of proteostasis and cellular senescence are key hallmarks of aging, but direct
cause-effect relationships are not well understood. We show that most yeast cells arrest in G1
before death with low ...
Study on the use of 3‐aminopropyltriethoxysilane and 3‐chloropropyltriethoxysilane to surface biochemical modification of a novel low elastic modulus Ti–Nb–Hf alloy
(Wiley, 2014-06-09)
A biocompatible new titanium alloy Ti–16Hf–25Nb with low elastic modulus (45 GPa) and the use of short bioadhesive peptides derived from the extracellular matrix have been studied. In terms of cell ...
Mechanical and physicochemical characterization along with biological interactions of a new Ti25Nb21Hf alloy for bone tissue engineering
(SAGE Publications, 2015-03-23)
Nowadays, one of the main challenges in metal implants for bone substitution is the achievement of an elastic modulus close to that of human cortical bone as well as to provide an adequate interaction ...
Comprehensive and quantitative analysis of G1 cyclins. A tool for studying the cell cycle
(Public Library of Science, 2019-06-25)
In eukaryotes, the cell cycle is driven by the actions of several cyclin dependent kinases (CDKs) and an array of regulatory proteins called cyclins, due to the cyclical expression patterns of the latter. ...