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Targeting the Src N-terminal regulatory element in cancer
(Impact Journals, 2023)
The signaling pathways displayed by cancer cells are often composed by the same components than the physiological ones, yet the overall result is a pathological deregulation. The non-receptor protein ...
Real-world epidemiology of potassium derangements among chronic cardiovascular, metabolic and renal conditions: a population-based analysis
(Dovepress, 2020)
Background: The aims of the present analysis are to estimate the prevalence of five key chronic cardiovascular, metabolic and renal conditions at the population level, the prevalence of renin–angioten ...
Complete loss of EPCAM immunoexpression identifies EPCAM deletion carriers in MSH2-negative colorectal neoplasia
(MDPI, 2020)
The use of epithelial cell adhesion molecule (EPCAM) immunohistochemistry (IHC) is not included in the colorectal cancer (CRC) screening algorithm to detect Lynch syndrome (LS) patients. The aim of the ...
90 years of progesterone: molecular mechanisms of progesterone receptor action on the breast cancer genome
(Bioscientifica Ltd., 2020)
Gene regulation by steroid hormones has been at the forefront in elucidating the intricacies of transcriptional regulation in eukaryotes ever since the discovery by Karlson and Clever that the insect ...
Role of the NUDT enzymes in breast cancer
(MDPI, 2021)
Despite global research efforts, breast cancer remains the leading cause of cancer death in women worldwide. The majority of these deaths are due to metastasis occurring years after the initial treatment ...
A perspective on the role of physiological stresses in cancer, diabetes and cognitive disease as environmental diseases
(Frontiers Media, 2023)
With rapid industrialization, urbanization, and climate change, the impact of environmental factors on human health is becoming increasingly evident and understanding the complex mechanisms involved is ...
Signalling network of breast cancer cells in response to progesterone
(Cold Spring Harbor Laboratory, 2020)
Breast cancer cells enter into the cell cycle following progestin exposure by the activation of signalling cascades involving a plethora of enzymes, transcription factors and co-factors that transmit ...
Correlation between tobacco control policies and mortality of haematological cancers across Europe: an ecological study
(European Publishing, 2021)
Introduction: To determine the correlation between tobacco control policies and mortality of haematological malignancies: leukemia, lymphoma and multiple myeloma (MM). Methods: Ecological study with the ...
Cpt1c downregulation causes plasma membrane remodelling and anthracycline resistance in breast cancer
(MDPI, 2023)
Breast cancer (BC) is the most common malignancy in women worldwide. While the main systemic treatment option is anthracycline-containing chemotherapy, chemoresistance continues to be an obstacle to ...
Functional genomics approaches to elucidate vulnerabilities of intrinsic and acquired chemotherapy resistance
(MDPI, 2021)
Drug resistance is a commonly unavoidable consequence of cancer treatment that results in therapy failure and disease relapse. Intrinsic (pre-existing) or acquired resistance mechanisms can be drug-specific ...