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Now showing items 121-130 of 375
Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking
(Rockefeller University Press, 2020)
Carnitine palmitoyltransferase 1C (CPT1C) is a sensor of malonyl-CoA and is located in the ER of neurons. AMPA receptors (AMPARs) mediate fast excitatory neurotransmission in the brain and play a key ...
Silver deposition on titanium surface by electrochemical anodizing process reduces bacterial adhesion of Streptococcus sanguinis and Lactobacillus salivarius
(Wiley, 2014-05-30)
Objectives: The aim of this study was to determine the antibacterial properties of silver‐doped titanium surfaces prepared with a novel electrochemical anodizing process. Material and methods: Titanium ...
Acute and chronic effects of competition on ankle dorsiflexion ROM in professional football players
(Taylor & Francis, 2020)
The aim of this study was to investigate the acute (a football match) and chronic (a whole season) effects of competition on ankle dorsiflexion ROM in professional football players. Forty football players ...
Liver CPT1A gene therapy reduces diet‐induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLD
(John Wiley & Sons, Inc., 2020)
The prevalence of nonalcoholic fatty liver disease (NAFLD) has increased drastically due to the global obesity pandemic but at present there are no approved therapies. Here, we aimed to revert high‐fat ...
Effect of an editorial intervention to improve the completeness of reporting of randomised trials: a randomised controlled trial
(BMJ Publishing Group, 2020)
Objective To evaluate the impact of an editorial intervention to improve completeness of reporting of reports of randomised trials. Design Randomised controlled trial (RCT). Setting BMJ Open’s quality ...
Determinants of study completion and response to a 12-month behavioral physical activity intervention in chronic obstructive pulmonary disease: a cohort study
(Public Library of Science, 2019-05-20)
Objectives: Physical activity is key to improve the prognosis of chronic obstructive pulmonary disease (COPD). To help to tailor future interventions we aimed to identify the baseline characteristics ...
SIRT3 deficiency exacerbates fatty liver by attenuating the HIF1α-LIPIN 1 pathway and increasing CD36 through Nrf2
(Springer Nature, 2020-09-10)
Background: Deficiency of mitochondrial sirtuin 3 (SIRT3), a NAD+-dependent protein deacetylase that maintains redox status and lipid homeostasis, contributes to hepatic steatosis. In this study, we ...
Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells
(Springer Nature, 2018)
With a diverse network of substrates, NUDIX hydrolases have emerged as a key family of nucleotide-metabolizing enzymes. NUDT5 (also called NUDIX5) has been implicated in ADP-ribose and 8-oxo-guanine ...
Validation of a loop-mediated isothermal amplification assay for rapid diagnosis of invasive pneumococcal disease
(Frontiers Media, 2020-03-24)
Current molecular PCR-based techniques used for detecting Streptococcus pneumoniae, the causative pathogen of invasive pneumococcal disease (IPD), are accurate but have a run time of several hours. We ...
Evaluation of the retinal nerve fiber layer Thickness, the mean deviation, and the visual field index in progressive glaucoma
(Wolters Kluwer Health, 2016)
PURPOSE: To determine and compare the retinal nerve fiber layer (RNFL) thickness, the mean deviation, and the visual field index (VFI) in glaucoma cases with progression detected by spectral domain ...