Visualitzant Ciències de la Salut per matèria "57"
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Functional consequences of transferrin receptor-2 mutations causing hereditary hemochromatosis type 3
(Molecular Genetics & Genomic Medicine, 2015)Hereditary hemochromatosis (HH) type 3 is an autosomal recessive disorder of iron metabolism characterized by excessive iron deposition in the liver and caused by mutations in the transferrin receptor ... -
Identification of conserved amino acid residues in rat liver carnitine palmitoyltransferase I critical for malonyl-CoA inhibition. Mutation of methionine 593 abolishes malonyl-CoA inhibition
(Journal of Biological Chemistry, 2003-03-14)Carnitine palmitoyltransferase (CPT) I, which catalyzes the conversion of palmitoyl-CoA to palmitoylcarnitine facilitating its transport through the mitochondrial membranes, is inhibited by malonyl-CoA. ... -
Impedimetric antimicrobial peptide-based sensor for the early detection of periodontopathogenic bacteria
(Biosensors and Bioelectronics, 2016-12-15)Peri-implantitis, an inflammation caused by biofilm formation, constitutes a major cause of implant failure in dentistry. Thus, the detection of bacteria at the early steps of biofilm growth represents ... -
The IronChip evaluation package: a package of perl modules for robust analysis of custom microarrays
(BMC Bioinformatics, 2010)Background: Gene expression studies greatly contribute to our understanding of complex relationships in gene regulatory networks. However, the complexity of array design, production and manipulations ... -
Mechanical and physicochemical characterization along with biological interactions of a new Ti25Nb21Hf alloy for bone tissue engineering
(Journal of Biomaterials Applications, 2015-03-23)Nowadays, one of the main challenges in metal implants for bone substitution is the achievement of an elastic modulus close to that of human cortical bone as well as to provide an adequate interaction ... -
Mimicking bone extracellular matrix: integrin-binding peptidomimetics enhance osteoblast-like cells adhesion, proliferation, and differentiation on titanium
(Colloids and Surfaces B: Biointerfaces, 2015-04-01)Interaction between the surface of implants and biological tissues is a key aspect of biomaterials research. Apart from fulfilling the non-toxicity and structural requirements, synthetic materials are ... -
Molecular evolution of multiple-level control of heme biosynthesis pathway in animal kingdom
(PLoS One, 2014)Adaptation of enzymes in a metabolic pathway can occur not only through changes in amino acid sequences but also through variations in transcriptional activation, mRNA splicing and mRNA translation. The ... -
MyoD induces ARTD1 and nucleoplasmic poly-ADP-ribosylation during fibroblast to myoblast transdifferentiation
(iScience, 2021)While protein ADP-ribosylation was reported to regulate differentiation and dedifferentiation, it has so far not been studied during transdifferentiation. Here, we found that MyoD-induced transdifferentiation ... -
Novel mutations in the ferritin-L iron-responsive element that only mildly impair IRP binding cause hereditary hyperferritinaemia cataract syndrome
(Orphanet Journal of Rare Diseases, 2013)Background: Hereditary Hyperferritinaemia Cataract Syndrome (HHCS) is a rare autosomal dominant disease characterized by increased serum ferritin levels and early onset of bilateral cataract. The disease ... -
Polyphosphate degradation by Nudt3-Zn2+ mediates oxidative stress response
(Cell Reports, 2021)Polyphosphate (polyP) is a polymer of hundreds of phosphate residues present in all organisms. In mammals, polyP is involved in crucial physiological processes, including coagulation, inflammation, and ... -
Protocol to quantify polyphosphate in human cell lines using a tagged PPBD peptide
(STAR Protocols, 2022)Polyphosphate (polyP) is an evolutionarily conserved polymer of phosphates that is difficult to study in human cells because of its low concentration and high lability. First, we described how to express ... -
Silver deposition on titanium surface by electrochemical anodizing process reduces bacterial adhesion of Streptococcus sanguinis and Lactobacillus salivarius
(Clinical Oral Implants Research, 2014-05-30)Objectives: The aim of this study was to determine the antibacterial properties of silver‐doped titanium surfaces prepared with a novel electrochemical anodizing process. Material and methods: Titanium ... -
Simulation methods with extended stability for stiff biochemical Kinetics
(BMC Systems Biology, 2010)Background: With increasing computer power, simulating the dynamics of complex systems in chemistry and biology is becoming increasingly routine. The modelling of individual reactions in (bio)chemical ... -
SIREs: searching for iron-responsive elements
(Nucleic Acids Research, 2010-07)The iron regulatory protein/iron-responsive element regulatory system plays a crucial role in the post-transcriptional regulation of gene expression and its disruption results in human disease. IREs are ... -
Study on the use of 3‐aminopropyltriethoxysilane and 3‐chloropropyltriethoxysilane to surface biochemical modification of a novel low elastic modulus Ti–Nb–Hf alloy
(Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2014-06-09)A biocompatible new titanium alloy Ti–16Hf–25Nb with low elastic modulus (45 GPa) and the use of short bioadhesive peptides derived from the extracellular matrix have been studied. In terms of cell ... -
Surface guidance of stem cell behavior: chemically tailored co-presentation of integrin-binding peptides stimulates osteogenic differentiation in vitro and bone formation in vivo
(Acta Biomaterialia, 2016-10-01)Surface modification stands out as a versatile technique to create instructive biomaterials that are able to actively direct stem cell fate. Chemical functionalization of titanium has been used in this ...