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Hypothalamic AMPK-ER Stress-JNK1 axis mediates the central actions of thyroid hormones on energy balance
(Cell Metabolism, 2017-07)Thyroid hormones (THs) act in the brain to modulate energy balance. We show that central triiodothyronine (T3) regulates de novo lipogenesis in liver and lipid oxidation in brown adipose tissue (BAT) ... -
Hypothalamic endocannabinoids in obesity: an old story with new challenges
(Cellular and Molecular Life Sciences, 2021)The crucial role of the hypothalamus in the pathogenesis of obesity is widely recognized, while the precise molecular and cellular mechanisms involved are the focus of intense research. A disrupted ... -
Hypothalamic endocannabinoids inversely correlate with the development of diet-induced obesity in male and female mice
(Journal of Lipid Research, 2019-07)The endocannabinoid (eCB) system regulates energy homeostasis and is linked to obesity development. However, the exact dynamic and regulation of eCBs in the hypothalamus during obesity progression remain ... -
Hypothalamic regulation of obesity
(International Journal of Molecular Sciences, 2021)Obesity has now reached pandemic proportions and represents a major socioeconomic and health problem in our societies. Up to now, obesity has been considered a medical issue only in high-income countries, ... -
Identification of conserved amino acid residues in rat liver carnitine palmitoyltransferase I critical for malonyl-CoA inhibition. Mutation of methionine 593 abolishes malonyl-CoA inhibition
(Journal of Biological Chemistry, 2003-03-14)Carnitine palmitoyltransferase (CPT) I, which catalyzes the conversion of palmitoyl-CoA to palmitoylcarnitine facilitating its transport through the mitochondrial membranes, is inhibited by malonyl-CoA. ... -
Identification of target mRNAs of regulatory RNA-binding proteins using mRNP immunopurification and microarrays
(Nature Protocols, 2007)RNA-binding proteins (RBPs) frequently regulate the post-transcriptional fate of target mRNAs. To identify novel target mRNAs of RBPs, we incubate total RNA with recombinant RBP and immunoselect the ... -
Identification of the ghrelin and cannabinoid CB2 receptor heteromer functionality and marked upregulation in striatal neurons from offspring of mice under a high-fat diet
(International Journal of Molecular Sciences, 2021)Cannabinoids have been reported as orexigenic, i.e., as promoting food intake that, among others, is controlled by the so-called “hunger” hormone, ghrelin. The aim of this paper was to look for functional ... -
The immediate effect of informational manual therapy for improving quiet standing and bodily pain in university population
(International Journal of Environmental Research and Public Health, 2021)Background: The Informational Manual Therapy (IMT) is a therapeutic touch. This study aims to assess the effect of IMT on quiet standing, pain and health status in university population. Methods: An ... -
Immediate effects of TECAR therapy on gastrocnemius and quadriceps muscles with spastic hypertonia in chronic stroke survivors: a randomized controlled trial
(Biomedicines, 2023)Background: The aim of this study was to assess changes in muscle properties after a single session of capacitive and resistive energetic transfer (TECAR) therapy on spastic gastrocnemius and quadriceps ... -
Immobilization of BMP-2 and VEGF within multilayered polydopamine-coated scaffolds and the resulting osteogenic and angiogenic synergy of co-cultured human mesenchymal stem cells and human endothelial progenitor cells
(International Journal of Molecular Sciences, 2020)We have previously reported the fabrication of a polycaprolactone and hydroxyapatite composite scaffold incorporating growth factors to be used for bone regeneration. Two growth factors were incorporated ... -
Impact of a long-term tobacco-free policy at a comprehensive cancer center: a series of cross-sectional surveys
(BMC Public Health, 2014)Background: Spain has passed two smoke-free laws in the last years. In 2005, the law banned smoking in indoor places, and in 2010 the ban was extended to outdoor areas of certain premises such as ... -
Impact of a multifaceted antimicrobial stewardship intervention in a primary health care area: a quasi-experimental study
(Frontiers in Pharmacology, 2020-04-02)The aim of the study was to evaluate the impact of a multifaceted antimicrobial stewardship intervention on antibiotic consumption in a primary health care (PHC) area in Spain. Quasi-experimental study ... -
Impact of changes in the WHO’s 2019 update of DDDs on the measurement of adult hospital antibacterial consumption in Catalonia (Spain), 2008–18
(JAC - Antimicrobial Resistance, 2022)Objectives: In 2019 the WHO fully adopted new DDD values. The objective of this study is to analyse their impact on the measurement of consumption of antibacterials in hospitals participating in the ... -
Impact of COVID-19 lockdown on the nasopharyngeal microbiota of children and adults self-confined at home
(Viruses, 2022)The increased incidence of COVID-19 cases and deaths in Spain in March 2020 led to the declaration by the Spanish government of a state of emergency imposing strict confinement measures on the population. ... -
Impact of perceived discrimination and coping strategies on well-being and mental health in newly-arrived migrants in Spain
(PloS one., 2023)To explore how perceived discrimination impacts the emotional well-being and mental health of newly-arrived migrants in Spain; and to identify the coping strategies and behavioral changes used to deal ... -
Impact of the 13-valent conjugated pneumococcal vaccine on the direct costs of invasive pneumococcal disease requiring hospital admission in children aged < 5 years: a prospective study
(Vaccines, 2020)The lack of invasive pneumococcal disease (IPD) cost studies may underestimate the eect of pneumococcal polysaccharide conjugated vaccines (PCV). The objective of this study was to estimate the direct ... -
Impact of the Bachelor's thesis on the nursing profession
(Nurse Education Today, 2015)Background: The Bologna Declaration ushered in the reform of higher education in 30 countries of the European Union (EU) and led to the establishment of the European Higher Education Area (EHEA), ... -
Impact of the bacterial nasopharyngeal microbiota on the severity of genus enterovirus lower respiratory tract infection in children: a case–control study
(Pediatric Pulmonology, 2023)Introduction: Rhinoviruses (RV) and enteroviruses (EV) are among the main causative etiologies of lower respiratory tract infection (LRTI) in children. The clinical spectrum of RV/EV infection is wide, ... -
Impact of transcranial direct current stimulation on sustained attention in breast cancer survivors: evidence for feasibility, tolerability, and initial efficacy
(Brain Stimulation, 2020)Background: A significant subset of breast cancer survivors experience cognitive difficulties in attention and memory, which persist for years following treatment. Transcranial direct current stimulation ... -
Impacto de la crisis económica en la actividad y eficiencia de un hospital terciario universitario
(Revista Española de Salud Pública, 2018)Fundamentos: La crisis económica iniciada el año 2008 provocó una caída importante del gasto sanitario público en España. El objetivo del estudio fue evaluar el impacto de la crisis en la actividad, ...