Impact of changes in the WHO’s 2019 update of DDDs on the measurement of adult hospital antibacterial consumption in Catalonia (Spain), 2008–18
Author
Grau, Santiago
Hernández Baeza, Sergi
Limón, Enric
Horcajada, Juan P.
Catalan Infection Control and Antimicrobial Stewardship National Program (VINCat-PROA)
Publication date
2022ISSN
2632-1823
Abstract
Objectives: In 2019 the WHO fully adopted new DDD values. The objective of this study is to analyse their impact on the measurement of consumption of antibacterials in hospitals participating in the Catalan Infection Control and Antimicrobial Stewardship National Program (VINCat-PROA) in Catalonia (Spain) between 2008 and 2018. Methods: The anatomical therapeutic chemical/DDD system was used to monitor adult hospital antibacterial consumption expressed in DDD/100 bed-days. Consumption from 2008 to 2018 was calculated using both pre- and post-update DDD values. Differences were calculated as the percentage variation in DDD/100 bed-days and analysed with Student’s t-test. Simple linear regressions were performed to evaluate the trends in adult antimicrobial consumption over the study period. Results: The overall consumption according to post-update DDD values decreased by 12.2% (P < 0.001) compared with the pre-update DDD values. Penicillins (−19.6.%; P < 0.001) and carbapenems (−19.0%; P = 0.023) showed the greatest reduction, followed by cephalosporins (−7.7%; P = 0.021) and quinolone antibacterials (−7.7%; P = 0.017). ICU services showed the greatest overall reduction (−13.1%; P < 0.001). From 2008 to 2018 there was a statistically significant decrease in consumption of penicillins and quinolone antibacterials and a statistically significant increase in cephalosporin and carbapenem consumption with both pre- and post-update DDD values. There were no variations in the ranking of consumption between the pre- and post-update DDD values. Conclusions: The WHO’s updates of DDDs have had a significant impact on the measurement of antibacterial consumption. In our region, they have corrected an overestimation of penicillin and carbapenem consumption amounting to 19%. It is essential to bear these findings in mind for an accurate assessment of temporal trends and benchmarking.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
61 - Medical sciences
Keywords
Penicilina
Carbapenem
Cefalosporinas
Adulto
Quinolonas
España
Organización Mundial de la Salud
Agentes antibacterianos
Penicil·lina
Carbapenem
Cefalosporines
Quinolones
Adultes
Espanya
Organització Mundial de la Salut
Agents antibacterians
Penicillin
Carbapenem
Cephalosporins
Adult
Quinolones
Spain
World Health Organization
Anti-bacterial agents
Pages
5
Publisher
Oxford University Press
Collection
2; 4
Is part of
JAC - Antimicrobial Resistance
Citation
Grau, Santiago; Hernández Baeza, Sergi; Limón, Enric [et al.]. Impact of changes in the WHO’s 2019 update of DDDs on the measurement of adult hospital antibacterial consumption in Catalonia (Spain), 2008–18. JAC - Antimicrobial Resistance, 2022, 2(4), [p. 1-5]. Disponible en: <https://academic.oup.com/jacamr/article/2/4/dlaa079/5925473>. Fecha de acceso: 4 oct. 2022. DOI: 10.1093/jacamr/dlaa079
Link to the related item
This item appears in the following Collection(s)
- Ciències de la Salut [738]
Rights
VC The Author(s) 2020. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by-nc/4.0/