Browsing Ciències de la Salut by Author "Villanueva, Alberto"

Now showing items 1-5 of 5

    • A truncated form of IKKa is responsible for specific nuclear IKK activity in colorectal cancer 

      Margalef, Pol; Fernández-Majada, Vanessa; Villanueva, Alberto; Garcia-Carbonell, Ricard; Iglesias, Mar; López, Laura; Martínez-Iniesta, María; Villà-Freixa, Jordi; Mulero, Mari Carmen; Andreu, Montserrat; Torres, Ferran; Mayo, Marty W.; Bigas, Anna; Espinosa, Lluis (Cell Reports, 2012-10-25)
      Nuclear IKKα regulates gene transcription by phosphorylating specific substrates and has been linked to cancer progression and metastasis. However, the mechanistic connection between tumorigenesis and ...

    • CDK6 is activated by the atypical cyclin I to promote E2F-mediated gene expression and cancer cell proliferation 

      Quandt, Eva; Masip, Núria; Hernández-Ortega, Sara; Sánchez-Botet, Abril; Gasa, Laura; Fernández-Elorduy, Ainhoa; Plutta, Sara; Martínez-Láinez, Joan Marc; Bru, Samuel; Munoz-Torres, Pau M.; Floor, Martin; Villà-Freixa, Jordi; Morris, May C.; Vidal, August; Villanueva, Alberto; Clotet, Josep; Ribeiro, Mariana P. C. (Molecular Oncology, 2023)
      Cyclin-dependent kinases (CDKs), together with their cyclin partners, are the master cell cycle regulators. Remarkably, the cyclin family was extended to include atypical cyclins, characterized by ...

    • CDK6 is activated by the atypical cyclin I to promote E2F-mediated gene expression and cancer cell proliferation 

      Quandt Herrera, Eva; Masip Sales, Núria; Hernández Ortega, Sara; Sánchez‑Botet, Abril; Gasa, Laura; Fernández-Elorduy, Ainhoa; Plutta, Sara; Martínez Láinez, Joan Marc; Bru Rullo, Samuel; Munoz-Torres, Pau M.; Floor, Martin; Villà-Freixa, Jordi; Morris, May C.; Vidal, August; Villanueva, Alberto; Clotet, Josep; Ribeiro, Mariana (Molecular Oncology, 2023)
      Cyclin-dependent kinases (CDKs), together with their cyclin partners, are the master cell cycle regulators. Remarkably, the cyclin family was extended to include atypical cyclins, characterized by ...

    • A systematic analysis of orphan cyclins reveals CNTD2 as a new oncogenic driver in lung cancer 

      Gasa Colom, Laura; Sánchez Botet, Abril; Quandt Herrera, Eva; Hernández Ortega, Sara; Jiménez Jiménez, Javier; Carrasco García, Miguel Ángel; Simonetti, Sara; Kron, Stephen J.; P.C. Ribeiro, Mariana; Nadal, E; Villanueva, Alberto; Clotet Erra, Josep (2017-08-31)
      As lung cancer has increased to the most common cause of cancer death worldwide, prognostic biomarkers and efective targeted treatments remain lacking despite advances based on patients’ stratifcation. ...

    • The atypical cyclin CNTD2 promotes colon cancer cell proliferation and migration 

      Sánchez Botet, Abril; Gasa Colom, Laura; Quandt Herrera, Eva; Hernández Ortega, Sara; Jiménez Jiménez, Javier; Mezquita Mas, Pau; Carrasco García, Miguel Ángel; Kron, Stephen J.; Vidal, August; Villanueva, Alberto; P.C. Ribeiro, Mariana; Clotet Erra, Josep (2018-08-07)
      Colorectal cancer (CRC) is one of the most common cancers worldwide, with 8–10% of these tumours presenting a BRAF (V600E) mutation. Cyclins are known oncogenes deregulated in many cancers, but the role ...