Competition in the chaperone-client network subordinates cell-cycle entry to growth and stress
Author
Moreno, David F.
Parisi, Eva
Yahya, Galal
Vaggi, Federico
Csikász-Nagy, Attila
Aldea Malo, Martí
Publication date
2019-04-15ISSN
2575-1077
Abstract
The precise coordination of growth and proliferation has a
universal prevalence in cell homeostasis. As a prominent
property, cell size is modulated by the coordination between
these processes in bacterial, yeast, and mammalian cells, but
the underlying molecular mechanisms are largely unknown.
Here, we show that multifunctional chaperone systems play a
concerted and limiting role in cell-cycle entry, specifically
driving nuclear accumulation of the G1 Cdk–cyclin complex.
Based on these findings, we establish and test a molecular
competition model that recapitulates cell-cycle-entry dependence on growth rate. As key predictions at a single-cell
level, we show that availability of the Ydj1 chaperone and nuclear accumulation of the G1 cyclin Cln3 are inversely dependent
on growth rate and readily respond to changes in protein
synthesis and stress conditions that alter protein folding requirements. Thus, chaperone workload would subordinate Start
to the biosynthetic machinery and dynamically adjust proliferation to the growth potential of the cell.
Document Type
Article
Document version
Accepted version
Language
English
Subject (CDU)
61 - Medical sciences
Keywords
Cicle cel·lular
Cell cycle
Cells
Cells--Growth-Molecular aspects
Células
Cèl·lules
Cèl·lules--Creixement--Aspectes moleculars
Pages
16
Publisher
Life Science Alliance
Collection
2; 2
Is part of
Life Science Alliance
Citation
Moreno, David F.; Parisi, Eva; Yahya, Galal; Vaggi, Federico; Csikasz-Nagy, Attila; Aldea Malo, Martí. «Competition in the chaperone-client network subordinates cell-cycle entry to growth and stress». Life Science Alliance, 2019, vol. 2, núm. 2, art. e201800277. Disponible en: <https://www.life-science-alliance.org/content/2/2/e201800277/tab-rc>. Fecha de acceso: 24 oct. 2019. DOI: 10.26508/lsa.201800277
This item appears in the following Collection(s)
- Ciències de la Salut [740]
Rights
http://creativecommons.org/licenses/by-nc-nd/4.0/
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-nd/4.0/