Growth rate as a direct regulator of the start network to set cell size
Author
Aldea Malo, Martí
Jenkins, Kirsten
Csikász-Nagy, Attila
Publication date
2017-05-26ISSN
2296-634X
Abstract
Cells are able to adjust their growth and size to external inputs to comply with specific
fates and developmental programs. Molecular pathways controlling growth also have
an enormous impact in cell size, and bacteria, yeast, or epithelial cells modify their
size as a function of growth rate. This universal feature suggests that growth (mass)
and proliferation (cell number) rates are subject to general coordinating mechanisms.
However, the underlying molecular connections are still a matter of debate. Here we
review the current ideas on growth and cell size control, and focus on the possible
mechanisms that could link the biosynthetic machinery to the Start network in budding
yeast. In particular, we discuss the role of molecular chaperones in a competition
framework to explain cell size control by growth at the individual cell level.
Document Type
Article
Document version
Accepted version
Language
English
Subject (CDU)
61 - Medical sciences
Keywords
Cells
Células
Cèl·lules
Cicle cel·lular
Cell cycle
Crecimiento celular
Cells-Growth
Size control
Budding yeast
Pages
6
Publisher
Frontiers Media
Collection
5;
Is part of
Frontiers in Cell and Developmental Biology
Citation
Aldea Malo, Martí; Jenkins, Kirsten; Csikász-Nagy, Attila. «Growth rate as a direct regulator of the start network to set cell size». Frontiers in Cell and Developmental Biology, 2017, vol. 5, art. 57. Disponible en: <https://www.frontiersin.org/articles/10.3389/fcell.2017.00057/full>. Fecha de acceso: 22 oct. 2019. DOI: 10.3389/fcell.2017.00057
This item appears in the following Collection(s)
- Ciències de la Salut [740]
Rights
http://creativecommons.org/licenses/by-nc-nd/4.0/
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-nd/4.0/