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Browsing by Author "Clotet Erra, Josep"

Now showing items 1-20 of 26

    • Atypical cyclin P regulates cancer cell stemness through activation of the WNT pathway 

      Sánchez‑Botet, Abril; Quandt Herrera, Eva; Masip, Núria; Escribá, Rubén; Novellasdemunt, Laura; Gasa Colom, Laura; Li, Vivian S. W.; Raya, Ángel; Clotet Erra, Josep; Ribeiro, Mariana P. C. (Cellular Oncology, 2021)
      Purpose: Cancer stem cells represent a cancer cell subpopulation that has been found to be associated with metastasis and chemoresistance. Therefore, it is vital to identify mechanisms regulating cancer ...

    • Atypical cyclins: the extended family portrait 

      Quandt Herrera, Eva; Ribeiro, Mariana P. C.; Clotet Erra, Josep (Cellular and Molecular Life Sciences, 2020)
      Regulation of cell division is orchestrated by cyclins, which bind and activate their catalytic workmates, the cyclin-dependent kinases (CDKs). Cyclins have been traditionally defined by an oscillating ...

    • Caracterización cuantitativa de las ciclinas de la fase G1 del ciclo celular en Saccharomyces cerevisiae 

      Bállega Moreno, Elisabet (Date of defense: 2017-11-07)
      Saccharomyces cerevisiae és un microorganisme unicel·lular eucariota que per presentar el seu genoma totalment seqüenciat, gran facilitat de manipulació en el treball de laboratori, ja que molts dels ...

    • Caracterización de complejos CDK-Ciclina atípicos humanos 

      Quandt Herrera, Eva (Date of defense: 2018-03-15)
      La desregulación en los mecanismos de control del ciclo celular es un evento indiscutiblemente asociado a la aparición de diversas patologías, entre las que destacan los procesos tumorales. Como principales ...

    • Caracterización molecular de nuevos substratos de la CDK Pho85 

      Ricco Pacheco, Natalia (Date of defense: 2013-07-29)
      La ciclina Cln3 es un activador crítico de START, cuya sobreexpresión provoca células de menor tamaño que progresan rápidamente por el ciclo celular, mientras que su deleción induce un mayor tamaño de ...

    • Centromeric signaling proteins boost G1 cyclin degradation and modulate cell size in budding yeast 

      Martínez-Láinez, Joan M.; Moreno, David F.; Parisi, Eva; Clotet Erra, Josep; Aldea Malo, Martí (PLoS Biology, 2018-08-06)
      Cell size scales with ploidy in a great range of eukaryotes, but the underlying mechanisms remain unknown. Using various orthogonal single-cell approaches, we show that cell size increases linearly ...

    • Comprehensive and quantitative analysis of G1 cyclins. A tool for studying the cell cycle 

      Ballega, Elisabet; Carballar Ruiz, María de los Reyes; Samper Martín, Bàrbara; Ricco Pacheco, Natalia; Ribeiro, Mariana P. C.; Bru Rullo, Samuel; Jiménez, Javier; Clotet Erra, Josep (PLoS One, 2019-06-25)
      In eukaryotes, the cell cycle is driven by the actions of several cyclin dependent kinases (CDKs) and an array of regulatory proteins called cyclins, due to the cyclical expression patterns of the latter. ...

    • Control de la estabilidad de ciclinas de G1 por nutrientes 

      Hernández Ortega, Sara (Date of defense: 2014-07-31)
      El control del ciclo celular está altamente regulado mediante diferentes CDKs asociadas a ciclinas. En Saccharomyces cerevisiae, la CDK esencial Cdc28 es la que regula mayoritariamente este proceso. En ...

    • CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity 

      Sierra, Adriana Y.; Gratacòs-Batlle, Esther; Carrasco, Patricia; Clotet Erra, Josep; Ureña, Jesús; Serra, Dolors; Asins, Guillermina; Hegardt, Fausto G.; Casals i Farré, Núria (Journal of Biological Chemistry, 2008)
      CPT1c is a carnitine palmitoyltransferase 1 (CPT1) isoform that is expressed only in the brain. The enzyme has recently been localized in neuron mitochondria. Although it has high sequence identity with ...

    • Defective in mitotic arrest 1 (Dma1) ubiquitin ligase controls G1 cyclin degradation 

      Hernández-Ortega, Sara; Bru Rullo, Samuel; Ricco Pacheco, Natalia; Ramírez, Sara; Casals i Farré, Núria; Jiménez, Javier; Isasa, Marta; Crosas, Bernat; Clotet Erra, Josep (Journal of Biological Chemistry, 2013-02)
      Progression through the G1 phase of the cell cycle is controlled by diverse cyclin-dependent kinases (CDKs) that might be associated to numerous cyclin isoforms. Given such complexity, regulation of ...

    • Efecto en la ingesta de chicles con distintas concentraciones de xilitol sobre el flujo, Ph y concentración de Streptococcus mutans salivares en niños de edades comprendidas entre 6 y 12 años 

      Ribelles Llop, Marta (Date of defense: 2016-07-14)
      La disminución de la caries dental no se ha producido de manera casual, sino que se debe a la aplicación satisfactoria de medidas preventivas adecuadas. Las estrategias preventivas se orientan hacia ...

    • El polifosfat és un element clau durant la replicació del DNA. 

      Bru Rullo, Samuel (Date of defense: 2015-11-06)
      Throughout its lifespan, eukaryotic cells steadily consume free cytoplasmic orthophosphate to produce phospholipids and mRNA. However, during DNA synthesis, in a matter of minutes, cells require large ...

    • Estudi de la ciclina atípica CCNI com a potencial activador de CDK6 en línies de càncer de mama 

      Masip Sales, Núria (Date of defense: 2022-02-09)
      Fa quasi 40 anys del descobriment de les ciclines, les proteïnes oscil·lants tradicionalment dividies en dos grups, “cicle cel·lular” i “ciclines transcripcionals”, que duen a terme els seus rols juntament ...

    • G1-Cdk modulation by time and stress 

      Pérez Paredes, Alexis E. (Date of defense: 2022-09-23)
      The cell cycle is regulated at different layers of control in either homeostatic or non-homeostatic conditions. Hence, in this work we analyse how time and stress modulate the cell cycle through the ...

    • La ciclina CNTD2: un nuevo inductor del desarrollo tumoral 

      Sánchez Botet, Abril (Date of defense: 2018-07-26)
      El cáncer colorrectal (CRC) es uno de los cánceres más comunes en todo el mundo, con un 8-10% de estos tumores que presentan una mutación BRAF (V600E). Las ciclinas son oncogenes comúnmente desregulados ...

    • Noves Ciclines: Omplint una escletxa a la Biologia del càncer 

      Gasa Colom, Laura (Date of defense: 2018-11-12)
      Les morts relacionades amb el càncer de pulmó han anat incrementant fins al punt que, actualment és una de les principals causes de mort per càncer al món. Tot i els avenços en aquesta malaltia basats ...

    • Nudt3. La primera endopolifosfatasa humana 

      Samper Martín, Bàrbara (Date of defense: 2020-10-15)
      El polifosfato inorgánico (polyP) es un polímero compuesto por cientos de residuos de fosfato (Pi) unidos por enlaces fosfoanhidro de alta energía. Esta molécula se encuentra en todos los organismos ...

    • Nutrient availability regulates cell cycle through a Pho85 CDK-dependent control of Cln3 cyclin stability 

      Menoyo Molins, Alexandra (Date of defense: 2013-02-04)
      Cell cycle control by trophic factors has a key role in regulation of cell proliferation in all organisms. Nutrients are one of these important factors needed by cells to reproduce, so very well regulated ...

    • Phosphoregulation of the oncogenic protein regulator of cytokinesis 1 (PRC1) by the atypical CDK16/CCNY complex 

      Hernández Ortega, Sara; Sánchez Botet, Abril; Quandt Herrera, Eva; Masip, Núria; Gasa Colom, Laura; Verde, Gaetano; Jiménez Jiménez, Javier; Levin, Rebecca; Rugatanira, Florentine U.; Burlingame, Alma L.; Wolfgeher, Donald; P.C. Ribeiro, Mariana; Kron, Stephen J.; M. Shokat, Kevan; Clotet Erra, Josep (2019)
      CDK16 (also known as PCTAIRE1 or PCTK1) is an atypical member of the cyclin-dependent kinase (CDK) family that forms an active complex with cyclin Y (CCNY). Although both proteins have been recently ...

    • Polyphosphate degradation by Nudt3-Zn2+ mediates oxidative stress response 

      Samper Martín, Bàrbara; Sarrias, Ana; Lázaro, Blanca; Pérez-Montero, Marta; Rodríguez-Rodríguez, Rosalía; P.C. Ribeiro, Mariana; Bañón, Aitor; Wolfgeher, Donald; Jessen, Henning J.; Alsina, Berta; Clotet Erra, Josep; Kron, Stephen J.; Saiardi, Adolfo; Jiménez, Javier; Bru Rullo, Samuel (Cell Reports, 2021)
      Polyphosphate (polyP) is a polymer of hundreds of phosphate residues present in all organisms. In mammals, polyP is involved in crucial physiological processes, including coagulation, inflammation, and ...