In vitro mitomycin C absorption and delivery with different sponge materials used in filtering surgery
Autor/a
Urbaneja Mejías, Diana
Morilla Grasa, Antonio
Jiménez, Elisa
Montemayor, Judith
Marcobal, Nuria
Aragay, Carme
Gurdiel, Celia
Armillas, Marta
Ortiz, Pere
Antón López, Alfonso
Data de publicació
2016-02-11ISSN
1177-5483
Resum
Purpose: The purpose of this study is to evaluate and compare mitomycin C (MMC) absorption and delivery in different materials used in filtering surgery.
Methods: This is an in vitro study comparing polyvinyl alcohol triangular sponges (TS6, TS8), polyvinyl alcohol fluid wicks (EFW), and absorbable gelatin sponges (AGS3, AGS5), from which five different types of transport units were obtained. Seven pieces of sponge of each transport unit type were obtained as follows: two transverse strips were obtained at 6 and 8 mm from the apex of TS and divided into three equal pieces; 4×4 mm pieces of EFW; 3×3 and 5×5 mm pieces of absorbable gelatin sponges were cut. Filter paper was placed on a precision scale (0.01 mg). The seven sponge pieces of each type were weighed three times consecutively in dry and wet states, the latter after immersion for 15 seconds in 0.2 mg/mL MMC. The difference between the weights of the dry and wet filter paper at the end of each measurement sequence was also calculated and considered as an estimate of the amount of mitomycin delivered.
Results: The amounts of MMC absorbed by each transport unit were as follows: (mean ± standard deviation) 27.43±5.13 for TS6, 31.91±6.63 for TS8, 15.96±2.23 for EFW, 17.96±2.05 for AGS3, and 33.81±2.05 for AGS5. The amounts of MMC delivered to the filter paper were as follows: 21.70±2.84 for TS6, 23.83±4.03 for TS8, 12.93±1.75 for EFW, 14.69±1.79 for AGS3, and 27.30±1.58 for AGS5.
Conclusion: Percentage MMC delivered was similar for all materials, but there was a tendency for greater delivery using larger sponges and greater homogeneity in delivery with AGS5. No statistical differences were found in percentage delivered by the different transport materials.
Tipus de document
Article
Versió del document
Versió acceptada
Llengua
English
Matèries (CDU)
61 - Medicina
617 - Cirurgia. Ortopèdia. Oftalmologia
Paraules clau
Oftalmologia
Glaucoma
Oftalmología
Ophthalmology
Ulls--Malalties
Ojos--Enfermedades
Eye--Diseases
Pàgines
5
Publicat per
Dove Medical Press
Col·lecció
10;
Publicat a
Clinical Ophthalmology
Citació
Urbaneja Mejías, Diana; Morilla Grasa, Antonio; Jiménez, Elisa; Montemayor, Judith; Marcobal, Nuria; Aragay, Carme; Gurdiel, Celia; Armillas, Marta; Ortiz, Pere; Antón López, Alfonso. «In vitro mitomycin C absorption and delivery with different sponge materials used in filtering surgery». Clinical Ophthalmology, 2016, vol. 10, p. 665-669. Disponible en: <https://www.dovepress.com/in-vitro-mitomycin-c-absorption-and-delivery-with-different-sponge-mat-peer-reviewed-article-OPTH>. Fecha de acceso: 26 sept. 2019. DOI: https://doi.org/10.2147/OPTH.S101345
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- Ciències de la Salut [740]
Drets
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