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A self-calibrating and multiplexed electrochemical lab-on-a-chip for cell culture analysis and high-resolution imaging
(Royal Society of Chemistry, 2020)
In vitro analysis requires cell proliferation in conditions close to physiological ones. Lab-on-a-chip (LoC) devices simplify, miniaturize and automate traditional protocols, with the advantages of being ...
Current challenges for targeting brown fat thermogenesis to combat obesity
(Frontiers Media S.A., 2020-10-27)
Just over a decade has passed since metabolically active brown adipose tissue (BAT) was unequivocally identified in healthy adult humans. Since then, researchers have provided evidence of expression of ...
Pomace olive oil concentrated in triterpenic acids restores vascular function, glucose tolerance and obesity progression in mice
(MDPI, 2020-01)
Pomace olive oil, an olive oil sub-product, is a promising source of bioactive triterpenoids such as oleanolic acid and maslinic acid. Considering the vascular actions of pomace olive oil and the potential ...
Editorial: current challenges for targeting brown fat thermogenesis to combat obesity
(Frontiers Media, 2020-10-27)
Just over a decade has passed since metabolically active brown adipose tissue (BAT) was unequivocally identified in healthy adult humans. Since then, researchers have provided evidence of expression of ...
Targeting carnitine palmitoyltransferase 1 isoforms in the hypothalamus: a promising strategy to regulate energy balance
(John Wiley & Sons, 2023)
Tackling the growing incidence and prevalence of obesity urgently requires uncovering new molecular pathways with therapeutic potential. The brain, and in particular the hypothalamus, is a major integrator ...
Polyphosphate degradation by Nudt3-Zn2+ mediates oxidative stress response
(Elsevier, 2021)
Polyphosphate (polyP) is a polymer of hundreds of phosphate residues present in all organisms. In mammals, polyP is involved in crucial physiological processes, including coagulation, inflammation, and ...
New insights of SF1 neurons in hypothalamic regulation of obesity and diabetes
(MDPI, 2021)
Despite the substantial role played by the hypothalamus in the regulation of energy balance and glucose homeostasis, the exact mechanisms and neuronal circuits underlying this regulation remain poorly ...
Sonochemical coating of Prussian Blue for the production of smart bacterial-sensing hospital textiles
(Elsevier, 2021-01)
In healthcare facilities, environmental microbes are responsible for numerous infections leading to patient’s health complications and even death. The detection of the pathogens present on contaminated ...
Carnitine palmitoyltransferase 1C negatively regulates the endocannabinoid hydrolase ABHD6 in mice, depending on nutritional status
(John Wiley & Sons, 2021-01)
Background and Purpose: The enzyme α/β‐hydrolase domain containing 6 (ABHD6), a new member of the endocannabinoid system, is a promising therapeutic target against neuronal‐related diseases. However, ...
SIRT3 deficiency exacerbates fatty liver by attenuating the HIF1α-LIPIN 1 pathway and increasing CD36 through Nrf2
(Springer Nature, 2020-09-10)
Background: Deficiency of mitochondrial sirtuin 3 (SIRT3), a NAD+-dependent protein deacetylase that maintains redox status and lipid homeostasis, contributes to hepatic steatosis. In this study, we ...