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Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells
(Nature Communications, 2018)With a diverse network of substrates, NUDIX hydrolases have emerged as a key family of nucleotide-metabolizing enzymes. NUDT5 (also called NUDIX5) has been implicated in ADP-ribose and 8-oxo-guanine ... -
Targeting carnitine palmitoyltransferase 1 isoforms in the hypothalamus: a promising strategy to regulate energy balance
(Journal of Neuroendocrinology, 2023)Tackling the growing incidence and prevalence of obesity urgently requires uncovering new molecular pathways with therapeutic potential. The brain, and in particular the hypothalamus, is a major integrator ... -
Targeting DNA repair defects for precision medicine in prostate cancer
(Current Oncology Reports, 2019)Purpose of Review: Genomic studies of localized and metastatic prostate cancer have identified a high prevalence of clinically actionable alterations including mutations in DNA repair genes. In this ... -
Targeting the oral plaque microbiome with immobilized anti-biofilm peptides at tooth-restoration interfaces
(PLoS ONE, 2020)Recurrent caries, the development of carious lesions at the interface between the restorative material and the tooth structure, is highly prevalent and represents the primary cause for failure of dental ... -
Targeting the Src N-terminal regulatory element in cancer
(Oncotarget, 2023)The signaling pathways displayed by cancer cells are often composed by the same components than the physiological ones, yet the overall result is a pathological deregulation. The non-receptor protein ... -
Task-dependent modulation of the visual sensory thalamus assists visual-speech recognition
(NeuroImage, 2018-09)The cerebral cortex modulates early sensory processing via feed-back connections to sensory pathway nuclei. The functions of this top-down modulation for human behavior are poorly understood. Here, we ... -
Teacher smiles as an interactional and pedagogical resource in the classroom
(Journal of Pragmatics, 2020)In classroom settings, laughter and smiles are resources for action that are available to both teachers and students. Recent interactional studies have documented how students use these resources to ... -
Telerehabilitation for balance rehabilitation in the subacute stage of stroke: a pilot controlled trial
(NeuroRehabilitation, 2022)BACKGROUND:Telerehabilitation has been proposed as an effective strategy to deliver post-stroke specific exercise. OBJECTIVE:To assess the effectiveness and feasibility of core stability exercises guided ... -
La televisión móvil: el estado de la cuestión
(Revista ICONO, 2010)El presente artículo recoge el estado de la cuestión de la investigación realizada sobre televisión en movilidad. Aunque la televisión para móvil es ahora mismo un objeto sobre-investigado, en el fondo ... -
Temperature and current flow effects of different electrode placement in shoulder capacitive-resistive electric transfer applications: a cadaveric study
(BMC Musculoskeletal Disorders, 2021)Background: Impingement syndrome is currently estimated to represent 60% of all shoulder pain disorders. Capacitive-Resistive electric transfer therapy is aimed to provoke temperature and current flow ... -
Temporal validation of a risk prediction model for breast cancer-related lymphoedema in European population: a retrospective study
(Journal of Advanced Nursing, 2023)Aims: To perform temporal validation of a risk prediction model for breast cancer-related lymphoedema in the European population. Design: Temporal validation of a previously developed prediction model ... -
La tendencia hacia la servitización en la gestión de la prevención de riesgos laborales
(Intangible Capital, 2014)Objeto: Este artículo tiene por objetivo examinar la relación existente entre la siniestralidad laboral y el tipo de servicio de prevención del que se provee la empresa. Diseño/metodología: Utilizando ... -
Territorios intermedios en la Región Metropolitana de Barcelona: identidad y reciclaje
(Ciudad y Territorio. Estudios Territoriales, 2010)La construcción del territorio metropolitano, únicamente guiada por criterios funcionales, deriva en su empobrecimiento visual y cívico. En este sentido, resultan especialmente preocupantes los extensos ... -
El Testamento en la Barcelona bajomedieval: la superación de la muerte patrimonial, social y espiritual, de Jaume Casamitjana i Vilaseca
(Revista de Dret Històric Català, 2007) -
Tetracycline and multidrug resistance in the oral microbiota: differences between healthy subjects and patients with periodontitis in Spain
(Journal of Oral Microbiology, 2020)Introduction: Antibiotic resistance is widely found even among bacterial populations not having been exposed to selective pressure by antibiotics, such as tetracycline. In this study we analyzed the ... -
El TFG como elemento de mejora de la calidad en la evaluación del módulo prácticum: propuesta de la Universitat Internacional de Catalunya (UIC)
(REDU. Revista de Docencia Universitaria, 2012-08)La evaluación de las prácticas educativas sigue, en general, un proceso sistemático que se articula en torno al eje tutor o tutora de la escuela, tutor o tutora de prácticas de la universidad y ... -
The actin binding protein profilin 2 is a novel regulator of iron homeostasis
(Blood, 2017)Cellular iron homeostasis is controlled by the iron regulatory proteins (IRPs) 1 and 2 that bind cis-regulatory iron-responsive elements (IRE) on target messenger RNAs (mRNA). We identified profilin 2 ... -
The atypical cyclin CNTD2 promotes colon cancer cell proliferation and migration
(2018-08-07)Colorectal cancer (CRC) is one of the most common cancers worldwide, with 8–10% of these tumours presenting a BRAF (V600E) mutation. Cyclins are known oncogenes deregulated in many cancers, but the role ... -
The Cerdà plan for the expansion of Barcelona: a model for modern city planning
(Focus, 2016-02-26)Modern city planning started with the Industrial Revolution and the scientific advances of the 19th Century. At the time, Catalan engineer Idelfons Cerdà coined the word "urbanism” as a new and necessary ... -
The contest determinant of delight and disappointment: a case study of online banking
(Total Quality Management & Business Excellence, 2013-05-07)Purpose: This study considers perceived online service quality and online service recovery as antecedents to online satisfaction for the purposes of investigating which factor has the most significant ...