Browsing Odontologia by Author "Aparicio, Conrado"
Now showing items 1-17 of 17
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Antimicrobial GL13K peptide coatings killed and ruptured the wall of streptococcus gordonii and prevented formation and growth of biofilms
Chen, Xi; Hirt, Helmut; Li, Yuping; Ulrik Gorr, Sven; Aparicio, Conrado (PLoS ONE, 2014)Infection is one of the most prevalent causes for dental implant failure. We have developed a novel antimicrobial peptide coating on titanium by immobilizing the antimicrobial peptide GL13K. GL13K was ... -
Biomimetic mineralized hybrid scaffolds with antimicrobial peptides
Ye, Zhou; Zhu, Xiao; Mutreja, Isha; Kumar Boda, Sunil; Fischer, Nicholas G.; Zhang, Anqi; Lui, Christine; Qi, Yipin; Aparicio, Conrado (Bioactive Materials, 2021-08)Infection in hard tissue regeneration is a clinically-relevant challenge. Development of scaffolds with dual function for promoting bone/dental tissue growth and preventing bacterial infections is a ... -
CAD-CAM and analog occlusal splints comparison based on the amount of occlusal adjustments. 3D analysis of the volumetric changes: A pilot study
Blasi, Alvaro; Henarejos-Domingo, Víctor; Palacios-Bañuelos, Ricardo; Vidal-Ponsoda, Carla; Aparicio, Conrado; Roig, Miguel (Journal of Esthetic and Restorative Dentistry, 2023)Objective: To evaluate the volumetric changes on occlusal surface of computer-aided design and computer-aided manufacturing (CAD-CAM) occlusal devices fabricated following a fully digital workflow after ... -
Chitosan-recombinamer layer-by-layer coatings for multifunctional implants
Prasaad Govindharajulu, Jeevan; Chen, Xi; Li, Yuping; Rodriguez-Cabello, J Carlos; Battacharya, Mrinal; Aparicio, Conrado (International Journal of Molecular Sciences, 2017)The main clinical problems for dental implants are (1) formation of biofilm around the implant—a condition known as peri-implantitis and (2) inadequate bone formation around the implant—lack of ... -
Culture and characterization of various porcine integumentary-connective tissue-derived mesenchymal stromal cells to facilitate tissue adhesion to percutaneous metal implants
Dey, Devaveena; Fischer, Nicholas G.; Dragon, Andrea H.; Ronzier, Elsa; Mutreja, Isha; Danielson, David T.; Homer, Cole J.; Forsberg, Jonathan A.; Bechtold, Joan E.; Aparicio, Conrado; Davis, Thomas A. (Stem Cell Research & Therapy, 2021)Background: Transdermal osseointegrated prosthesis have relatively high infection rates leading to implant revision or failure. A principle cause for this complication is the absence of a durable ... -
Development of standard protocols for biofilm-biomaterial interface testing
Cieplik, Fabian; Aparicio, Conrado; Kreth, Jens; Schmalz, Gottfried (JADA Foundational Science, 2022)The oral biofilm is associated with the most common oral diseases such as caries, periodontitis, and peri-implantitis. It is also linked to failures of dental treatment approaches (eg, direct or indirect ... -
Discerning the subfibrillar structure of mineralized collagen fibrils: a model for the ultrastructure of bone
Li, Yuping; Aparicio, Conrado (PLoS ONE, 2013)Biomineralization templated by organic molecules to produce inorganic-organic nanocomposites is a fascinating example of nature using bottom-up strategies at nanoscale to accomplish highly ordered ... -
Functional signatures of ex-vivo dental caries onset
Moussa, Dina; Sharma, Ashok K.; Mansour, Tamer; Witthuhn, Bruce; Perdigao, Jorge; Rudney, Joel D.; Aparicio, Conrado; Gomez, Andres (Journal of Oral Microbiology, 2022)Background: The etiology of dental caries remains poorly understood. With the advent of next-generation sequencing, a number of studies have focused on the microbial ecology of the disease. However, ... -
Guiding bone formation using semi-onlay calcium phosphate implants in an ovine calvarial model
Hulsart-Billström, Gry; Lopes, Viviana; Illies, Christopher; Gallinetti, Sara; Aberg, Jonas; Engqvist, Hakan; Aparicio, Conrado; Larsson, Sune; Burenstam Linder, Lars; Birgersson, Ulrik (Journal of Tissue Engineering and Regenerative Medicine, 2022)The restoration of cranio-maxillofacial deformities often requires complex reconstructive surgery in a challenging anatomical region, with abnormal soft tissue structures and bony deficits. In this ... -
Human whole blood interactions with craniomaxillofacial reconstruction materials: exploring In vitro the role of blood cascades and leukocytes in early healing events
Lopes, Viviana; Birgersson, Ulrik; Anand, Vivek; Hulsart-Billström, Gry; Gallinetti, Sara; Aparicio, Conrado; Hong, Jaan (Journal of Functional Biomaterials, 2023)The present study investigated early interactions between three alloplastic materials (calcium phosphate (CaP), titanium alloy (Ti), and polyetheretherketone (PEEK) with human whole blood using an ... -
Implant surface physicochemistry affects keratinocyte hemidesmosome formation
Raptopoulos, Michail; Fischer, Nicholas G.; Aparicio, Conrado (Journal of Biomedical Materials Research Part A, 2023)Previous studies have shown hydrophilic/hydrophobic implant surfaces stimulate/hinder osseointegration. An analogous concept was applied here using common biological functional groups on a model surface ... -
Influence of titanium surface residual stresses on osteoblastic response and bacteria colonization
Pereira, Rita; Maia, Paulo; Ríos-Santos, JV; Herrero-Climent, Mariano; Ríos Carrasco, Blanca; Aparicio, Conrado; Gil, FJ (Materials, 2024)Grit basting is the most common process applied to titanium dental implants to give them a roughness that favors bone colonization. There are numerous studies on the influence of roughness on osseointegration, ... -
Junctional epithelium and hemidesmosomes: tape and rivets for solving the “percutaneous device dilemma” in dental and other permanent implants
Fischer, Nicholas G.; Aparicio, Conrado (Bioactive Materials, 2022-12)The percutaneous device dilemma describes etiological factors, centered around the disrupted epithelial tissue surrounding non-remodelable devices, that contribute to rampant percutaneous device infection. ... -
PLA-based mineral-doped scaffolds seeded with human periapical cyst-derived MSCs: a promising tool for regenerative healing in dentistry
Tatullo, Marco; Spagnuolo, Gianrico; Codispoti, Bruna; Zamparini, Fausto; Zhang, Anqi; Degli Esposti, Micaela; Aparicio, Conrado; Rengo, Carlo; Nuzzolese, Manuel; Manzoli, Lucia; Fava, Fabio; Prati, Carlo; Fabbri, Paola; Giovanna Gandolfi, Maria (Materials, 2019)Human periapical cyst mesenchymal stem cells (hPCy-MSCs) are a newly discovered cell population innovatively collected from inflammatory periapical cysts. The use of this biological waste guarantees a ... -
Relevant aspects of piranha passivation in Ti6Al4V alloy dental meshes
Cruz, Nuno; Gil Mur, Francisco Javier; Punset fuste, Miquel; Manero, José María; tondela, joão paulo; Verdeguer, Pablo; Aparicio, Conrado; Ruperez, Elisa (Coatings, 2022)Passivation of titanium alloy dental meshes cleans their surface and forms a thin layer of protective oxide (TiO2) on the surface of the material to improve resistance to corrosion and prevent release ... -
Surface immobilization chemistry of a laminin-derived peptide affects keratinocyte activity
Fischer, Nicholas; He, Jiahe; Aparicio, Conrado (Coatings, 2020)Many chemical routes have been proposed to immobilize peptides on biomedical device surfaces, and in particular, on dental implants to prevent peri-implantitis. While a number of factors affect peptide ... -
Targeting the oral plaque microbiome with immobilized anti-biofilm peptides at tooth-restoration interfaces
Moussa, Dina G.; Aparicio, Conrado (PLoS ONE, 2020)Recurrent caries, the development of carious lesions at the interface between the restorative material and the tooth structure, is highly prevalent and represents the primary cause for failure of dental ...